A COUNTERMEASURE FOR SLEEP LOSS IN OLDER ADULTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 慢性失眠症的患病率随着年龄的增长而增加。 最近的研究结果表明，除了对认知和表现的不利影响外，睡眠不足也对健康产生负面影响，这与代谢，心血管和免疫健康措施中与年龄相关的变化相似。 尽管伴随着衰老过程的慢性睡眠丧失会产生重要的医学和社会后果，但老年人缺乏安全有效的治疗策略。 睡眠问题的慢性性质，加上催眠药物的副作用，限制了药物治疗老年人失眠的有效性。 因此，需要开发用于管理老年人失眠的替代、安全和有效的方法。 最近的研究结果表明，运动可以改善老年人的睡眠质量。 这项拟议研究的目标是确定运动改善老年失眠症患者睡眠、健康、日间表现和整体生活质量的能力。 具体目标1是确定运动和睡眠卫生教育对失眠老年人睡眠质量、睡眠量、昼夜节律、日间表现、情绪和生活质量的客观和主观指标的影响。 这些客观和主观测量将在16周有氧运动计划（每周3-4次）之前和之后的3天住院期间进行。 对照组在16周的睡眠卫生教育干预前后采取相同的措施。 具体目标2是确定有氧运动和睡眠质量和数量的改善对健康措施的影响。 在16周运动干预或睡眠卫生教育干预之前和之后，将测量代谢、内分泌和心血管以及其他衰老生物标志物，如骨转换、自主和免疫参数（IL-6、TNF-α和C-反应蛋白）。 这些研究不仅将确定运动是否是治疗老年人失眠的有效方法，还将提高我们对老年人睡眠与健康之间关系的理解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The prevalence of chronic insomnia increases with age. Recent findings demonstrate that in addition to its detrimental effects on cognition and performance, sleep loss also has a negative impact on health that is similar to age-related changes in metabolic, cardiovascular, and immune measures of health. Despite the important medical and social consequences of chronic sleep loss that accompany the aging process, there is a paucity of safe and effective treatment strategies for the elderly. The chronic nature of the sleep problems, coupled with the side effects of hypnotic medications, limit the usefulness of pharmacological approaches for the treatment of insomnia in this older population. Therefore, there is a need to develop alternative, safe and effective approaches for the management of insomnia in older adults. Recent findings indicate that exercise can improve sleep quality in older adults. The goal of the proposed research is to determine the ability of exercise to improve sleep, health, daytime performance and overall quality of life in older adults with insomnia. Specific aim 1 is to determine the effects of exercise and sleep hygiene education on objective and subjective measures of sleep quality, sleep quantity, circadian rhythms, daytime performance, mood and quality of life in older adults with insomnia. These objective and subjective measures will be taken during a 3-day admission to the General Clinical Research Center before and after a 16-week aerobic exercise program (3-4 sessions per week). The same measures will be taken in a control group before and after a 16-week sleep hygiene education intervention with structured activity. Specific aim 2 is to determine the effects of the aerobic exercise and improvements in sleep quality and quantity on measures of health. Measurements of metabolic, endocrine and cardiovascular, as well as other bio-markers of aging such as bone turnover, autonomic and immune parameters (IL-6, TNF-alpha and C-reactive protein) will be taken before and after the 16-week exercise intervention or sleep hygiene education intervention. The proposed studies will not only determine whether exercise is an effective approach for the management of insomnia in the elderly, but will also improve our understanding of the relationship between sleep and health in older adults.