SLEEP AND CIRCADIAN GENETICS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 近年来，在揭示哺乳动物昼夜节律产生的分子基础方面取得了很大进展。对啮齿动物的分子研究刺激了对基因差异的搜索，这些差异可能是人类昼夜节律改变和/或睡眠障碍的基础。人类最常见的两种睡眠障碍被认为是由于昼夜节律的改变而引起的，这两种睡眠障碍被归类为延迟睡眠阶段(DSP)和高级睡眠阶段(ASP)。DSP的特点是持续无法在凌晨2点到6点之前开始睡眠，直到上午10点到1点才能醒来，而ASP的特点是习惯性和非自愿的睡眠和醒来时间至少比社会平均水平早几个小时。对DSP和ASP的遗传学基础的研究为阐明睡眠-觉醒和昼夜节律系统如何相互整合，以及特定生物钟基因的改变如何导致睡眠和觉醒时间的改变提供了一条新的令人兴奋的途径。本研究的目的是确定DSP和ASP的分子遗传学基础。受试者将已经参与了IRB研究533-036，这是一项筛查研究，以确认DSP、ASP或控制状态。将抽取一份血液样本(不到4汤匙)，用于未来的基因分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recent years great progress has been made in uncovering the molecular basis for the generation of circadian rhythms in mammals. Molecular studies in rodents have stimulated a search for genetic differences that could underlie altered circadian rhythms and/or sleep disorders in humans. Two of the most common sleep disorders in humans that are thought to be due to alterations in circadian timing are classified as the Delayed Sleep Phase (DSP) and Advanced Sleep Phase (ASP). DSP is characterized by a persistent inability to initiate sleep before 2 to 6 AM and difficulty waking up until 10 AM to 1 PM, whereas, ASP is characterized by habitual and involuntary sleep and wake times that are at least several hours earlier than societal means. Studies on the genetic basis of DSP and ASP represent a new and exciting avenue to elucidate how the sleep-wake and circadian systems are integrated with each other, and how alterations in specific circadian clock genes can lead to alterations in the timing of sleep and wake. The aim of this study is to determine the molecular genetic basis for DSP and ASP. Subjects will have already participated in IRB study 533-036, a screening study to confirm DSP, ASP or control status. A blood sample (less than 4 tablespoons) will be drawn for future analysis of genes.