SLEEP AND CIRCADIAN GENETICS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 近年来，在揭示哺乳动物昼夜节律产生的分子基础方面取得了很大进展。 对啮齿动物的分子研究刺激了对可能导致人类昼夜节律改变和/或睡眠障碍的遗传差异的研究。 人类最常见的两种睡眠障碍被认为是由于昼夜节律的改变，被分类为延迟睡眠阶段（DSP）和高级睡眠阶段（ASP）。 DSP的特征在于持续无法在2至6 AM之前开始睡眠，并且难以在10 AM至1 PM之前醒来，而ASP的特征在于习惯性和非自愿的睡眠和唤醒时间比社会平均值早至少几个小时。 DSP和ASP的遗传基础的研究代表了一个新的和令人兴奋的途径来阐明睡眠-觉醒和昼夜节律系统是如何相互整合的，以及特定昼夜节律钟基因的改变如何导致睡眠和觉醒时间的改变。 本研究的目的是确定DSP和ASP的分子遗传基础。 受试者将已参加IRB研究533-036，这是一项确认DSP、ASP或对照状态的筛选研究。 将抽取血液样本（少于4汤匙）用于未来的基因分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recent years great progress has been made in uncovering the molecular basis for the generation of circadian rhythms in mammals. Molecular studies in rodents have stimulated a search for genetic differences that could underlie altered circadian rhythms and/or sleep disorders in humans. Two of the most common sleep disorders in humans that are thought to be due to alterations in circadian timing are classified as the Delayed Sleep Phase (DSP) and Advanced Sleep Phase (ASP). DSP is characterized by a persistent inability to initiate sleep before 2 to 6 AM and difficulty waking up until 10 AM to 1 PM, whereas, ASP is characterized by habitual and involuntary sleep and wake times that are at least several hours earlier than societal means. Studies on the genetic basis of DSP and ASP represent a new and exciting avenue to elucidate how the sleep-wake and circadian systems are integrated with each other, and how alterations in specific circadian clock genes can lead to alterations in the timing of sleep and wake. The aim of this study is to determine the molecular genetic basis for DSP and ASP. Subjects will have already participated in IRB study 533-036, a screening study to confirm DSP, ASP or control status. A blood sample (less than 4 tablespoons) will be drawn for future analysis of genes.