SLEEP AND CIRCADIAN GENETICS
SLEEP AND CIRCADIAN GENETICS
批准号:
7604331
负责人:
Phyllis C. Zee
金额:
$0.27万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-12-01 至 2007-11-30
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
In recent years great progress has been made in uncovering the molecular basis for the generation of circadian rhythms in mammals. Molecular studies in rodents have stimulated a search for genetic differences that could underlie altered circadian rhythms and/or sleep disorders in humans. Two of the most common sleep disorders in humans that are thought to be due to alterations in circadian timing are classified as the Delayed Sleep Phase (DSP) and Advanced Sleep Phase (ASP). DSP is characterized by a persistent inability to initiate sleep before 2 to 6 AM and difficulty waking up until 10 AM to 1 PM, whereas, ASP is characterized by habitual and involuntary sleep and wake times that are at least several hours earlier than societal means. Studies on the genetic basis of DSP and ASP represent a new and exciting avenue to elucidate how the sleep-wake and circadian systems are integrated with each other, and how alterations in specific circadian clock genes can lead to alterations in the timing of sleep and wake. The aim of this study is to determine the molecular genetic basis for DSP and ASP. Subjects will have already participated in IRB study 533-036, a screening study to confirm DSP, ASP or control status. A blood sample (less than 4 tablespoons) will be drawn for future analysis of genes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Strengthening circadian signals to enhance cardiometabolic function
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批准号:10178077
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项目类别:
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资助金额:$68.29万
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财政年份:2017
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负责人:Phyllis C. Zee
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依托单位:
A COUNTERMEASURE FOR SLEEP LOSS IN OLDER ADULTS
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批准号:7604254
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项目类别:
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资助金额:$5.53万
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财政年份:2006
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负责人:Phyllis C. Zee
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依托单位:
THE NEURAL RESPONSE TO SLEEP LOSS IN THE ELDERLY
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批准号:7604243
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项目类别:
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资助金额:$0.14万
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财政年份:2006
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负责人:Phyllis C. Zee
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依托单位:
LIGHT-INDUCED SUPPRESSION OF MELATONIN IN ADVANCED AND DELAYED SLEEP
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批准号:7604273
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项目类别:
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资助金额:$0.18万
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财政年份:2006
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负责人:Phyllis C. Zee
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依托单位:
SLEEP-RELATED ENDOCRINE PROFILES IN SUBJECTS WITH CIRCADIAN PHASE DISORDERS
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批准号:7604267
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项目类别:
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资助金额:$10.33万
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财政年份:2006
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负责人:Phyllis C. Zee
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依托单位:
SLEEP-RELATED ENDOCRINE PROFILES IN SUBJECTS WITH CIRCADIAN PHASE DISORDERS
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批准号:7376862
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项目类别:
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资助金额:$7.6万
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财政年份:2005
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负责人:Phyllis C. Zee
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依托单位:
AGE RELATED EFFECTS OF SLEEP DEPRIVATION ON CEREBRAL CORTICAL ACTIVITATION
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批准号:7376829
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项目类别:
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资助金额:$19.51万
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财政年份:2005
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负责人:Phyllis C. Zee
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依托单位:
LIGHT-INDUCED SUPPRESSION OF MELATONIN IN ADVANCED AND DELAYED SLEEP
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批准号:7376871
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项目类别:
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资助金额:$4.81万
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财政年份:2005
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负责人:Phyllis C. Zee
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依托单位:
A COUNTERMEASURE FOR SLEEP LOSS IN OLDER ADULTS
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批准号:7376844
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项目类别:
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资助金额:$6.25万
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财政年份:2005
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负责人:Phyllis C. Zee
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依托单位:
A COUNTERMEASURE FOR SLEEP LOSS IN OLDER ADULTS
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批准号:7200448
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项目类别:
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资助金额:$3.18万
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财政年份:2004
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负责人:Phyllis C. Zee
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依托单位:
GENETIC COMPONENTS OF ADVANCED AND DELAYED SLEEP PHASE SYNDROME
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批准号:7200426
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项目类别:
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资助金额:$0.28万
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财政年份:2004
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负责人:Phyllis C. Zee
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依托单位:
CHARACTERIZATION OF CIRCADIAN RHYTHMS, SLEEP AND SLEEP-RELATED PROFILES
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批准号:7200472
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项目类别:
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资助金额:$1.66万
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财政年份:2004
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负责人:Phyllis C. Zee
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依托单位:
A Countermeasure for Sleep Loss in Older Adults
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批准号:7040386
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项目类别:
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资助金额:$1.04万
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财政年份:2003
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负责人:Phyllis C. Zee
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依托单位:
Sleep/Wake Rhythms in Aging: Responsiveness of the Clock to Light
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批准号:7040341
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项目类别:
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资助金额:$0.85万
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财政年份:2003
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负责人:Phyllis C. Zee
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依托单位:
Circadian rhythms and sleep in familial DSPS and ASPS
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批准号:6580035
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项目类别:
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资助金额:$37.13万
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财政年份:2003
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负责人:Phyllis C. Zee
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依托单位:
Circadian rhythms and sleep in familial DSPS and ASPS
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批准号:6930450
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项目类别:
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资助金额:$37.13万
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财政年份:2003
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负责人:Phyllis C. Zee
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依托单位:
Genetic Components of Advanced and Delayed Sleep Phase Syndrome
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批准号:7040351
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项目类别:
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资助金额:$0.78万
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财政年份:2003
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负责人:Phyllis C. Zee
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依托单位:
Circadian rhythms and sleep in familial DSPS and ASPS
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批准号:7076267
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项目类别:
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资助金额:$36.25万
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财政年份:2003
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负责人:Phyllis C. Zee
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依托单位:
Circadian rhythms and sleep in familial DSPS and ASPS
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批准号:7264002
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项目类别:
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资助金额:$35.2万
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财政年份:2003
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负责人:Phyllis C. Zee
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依托单位:
Circadian rhythms and sleep in familial DSPS and ASPS
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批准号:6787244
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项目类别:
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资助金额:$37.13万
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财政年份:2003
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负责人:Phyllis C. Zee
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依托单位:
海外基金