AGE RELATED EFFECTS OF SLEEP DEPRIVATION ON CEREBRAL CORTICAL ACTIVITATION

睡眠剥夺对大脑皮层激活的年龄相关影响

• 批准号: 7376829
• 负责人: Phyllis C. Zee
• 金额: $ 19.51万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376829
• 关键词: AGE; RELATED; EFFECTS; SLEEP; DEPRIVATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sleep deprivation is common among the adult population, and the effects of sleep deprivation have been studied using cognitive performance and neuropsychological testing. It has been shown that cognitive performance declines in response to sleep deprivation. In order to determine why cognitive performance declines during sleep deprivation it must be addressed as to how neuronal firing and blood flow changes in the sleep deprived brain. Functional Magnetic Resonance Imaging (fMRI) is one tool available to measure blood flow changes via the Blood Oxygenation Level Dependent method (BOLD) in the sleep deprived brain and can be conducted during various cognitive performance tests. The overall goal of this project is to understand how the brain responds to sleep deprivation in younger and older adults using fMRI and cognitive testing. It is hypothesized that older adults will have more difficulty than younger adults in recruiting the prefrontal cortex in working memory-related and visual-spatial tasks after 36 hours of sleep deprivation, as measured by the fMRI. Results from these studies will provide insight into the mechanisms underlying how the brain responds to sleep deprivation, why cognitive performance changes in response to sleep deprivation, and how aging alters these mechanisms. The specific aims of this proposal are 1) To test the hypothesis that the sleep deprived brain compensates during certain cognitive tasks by increasing blood flow to the regions of the brain most involved in performing those tasks, 2) To test the hypothesis that in aging cognitive performance declines more rapidly in response to sleep deprivation, and 3) To test the hypothesis that in aging there will be a change in cortical Activation compared to younger subjects during a sleep-deprived state, resulting in less blood flow to certain brain regions during cognitive testing. 4) To localize cerebral cortical areas that are susceptible to Sleep Deprivation 5) to determine sleep recovery following 36 hours of sleep deprivation in young and older subjects.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。睡眠剥夺在成年人群中很普遍，并且已经使用认知表现和神经心理学测试对睡眠剥夺的影响进行了研究。已经表明，认知表现会因睡眠剥夺而下降。为了确定为什么在睡眠剥夺期间认知表现下降，必须解决神经元的发射和血液流动如何变化的睡眠剥夺大脑。功能磁共振成像（fMRI）是一种可通过在睡眠剥夺大脑中的血液氧合水平依赖性方法（BOLD）来测量血流变化的工具，可以在各种认知性能测试中进行。该项目的总体目标是了解使用fMRI和认知测试的大脑如何应对年轻和老年人的睡眠剥夺。假设老年人在36小时的睡眠剥夺后，老年人在招募与工作记忆相关和视觉空间任务的前额叶皮层方面的困难将更加困难。这些研究的结果将提供有关大脑对睡眠剥夺方式反应方式的机制的洞察力，为什么认知表现会对睡眠剥夺的反应变化以及衰老如何改变这些机制。 The specific aims of this proposal are 1) To test the hypothesis that the sleep deprived brain compensates during certain cognitive tasks by increasing blood flow to the regions of the brain most involved in performing those tasks, 2) To test the hypothesis that in aging cognitive performance declines more rapidly in response to sleep deprivation, and 3) To test the hypothesis that in aging there will be a change in cortical Activation compared to younger subjects during a sleep-deprived状态，导致在认知测试期间流向某些大脑区域的血液较少。 4）要定位容易患睡眠剥夺的脑皮质区域5）在年轻和老年受试者的睡眠剥夺36小时后确定睡眠恢复。