AGE RELATED EFFECTS OF SLEEP DEPRIVATION ON CEREBRAL CORTICAL ACTIVITATION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。睡眠剥夺在成年人中很常见，睡眠剥夺的影响已经通过认知表现和神经心理学测试进行了研究。研究表明，睡眠不足会导致认知能力下降。为了确定为什么在睡眠剥夺期间认知能力下降，必须解决在睡眠剥夺的大脑中神经元放电和血液流动是如何变化的问题。功能磁共振成像（fMRI）是一种可用的工具，通过血氧水平依赖方法（BOLD）在睡眠剥夺的大脑中测量血流量变化，可以在各种认知表现测试中进行。这个项目的总体目标是通过功能磁共振成像和认知测试来了解大脑对年轻人和老年人睡眠不足的反应。据推测，在36小时的睡眠剥夺后，老年人在工作记忆和视觉空间任务中比年轻人更难调动前额叶皮层。这些研究的结果将深入了解大脑对睡眠剥夺的反应机制，为什么认知表现会对睡眠剥夺做出反应，以及衰老如何改变这些机制。这个提案的具体目标1)来测试假设被剥夺睡眠的大脑补偿在特定认知任务通过增加大脑血液流动区域的大多数参与执行这些任务,2)来测试假设认知老化性能下降更快睡眠不足,和3)在老化测试的假设会有皮质激活的变化相比,年轻受试者在睡眠状态,导致在认知测试中流向大脑特定区域的血流量减少。4)定位易受睡眠剥夺影响的大脑皮层区域5)测定年轻人和老年人36小时睡眠剥夺后的睡眠恢复情况。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sleep deprivation is common among the adult population, and the effects of sleep deprivation have been studied using cognitive performance and neuropsychological testing. It has been shown that cognitive performance declines in response to sleep deprivation. In order to determine why cognitive performance declines during sleep deprivation it must be addressed as to how neuronal firing and blood flow changes in the sleep deprived brain. Functional Magnetic Resonance Imaging (fMRI) is one tool available to measure blood flow changes via the Blood Oxygenation Level Dependent method (BOLD) in the sleep deprived brain and can be conducted during various cognitive performance tests. The overall goal of this project is to understand how the brain responds to sleep deprivation in younger and older adults using fMRI and cognitive testing. It is hypothesized that older adults will have more difficulty than younger adults in recruiting the prefrontal cortex in working memory-related and visual-spatial tasks after 36 hours of sleep deprivation, as measured by the fMRI. Results from these studies will provide insight into the mechanisms underlying how the brain responds to sleep deprivation, why cognitive performance changes in response to sleep deprivation, and how aging alters these mechanisms. The specific aims of this proposal are 1) To test the hypothesis that the sleep deprived brain compensates during certain cognitive tasks by increasing blood flow to the regions of the brain most involved in performing those tasks, 2) To test the hypothesis that in aging cognitive performance declines more rapidly in response to sleep deprivation, and 3) To test the hypothesis that in aging there will be a change in cortical Activation compared to younger subjects during a sleep-deprived state, resulting in less blood flow to certain brain regions during cognitive testing. 4) To localize cerebral cortical areas that are susceptible to Sleep Deprivation 5) to determine sleep recovery following 36 hours of sleep deprivation in young and older subjects.