PREDNISONE PHARMACOKINETICS IN JUVENILE DERMATOMYOSITIS

泼的松在青少年皮肌炎中的药代动力学

• 批准号: 7604233
• 负责人: LAUREN M. PACHMAN
• 金额: $ 0.27万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604233
• 关键词: PREDNISONE; PHARMACOKINETICS; JUVENILE; DERMATOMYOSITIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypersensitivity vasculitis in some children with connective tissue disease is characterized by increased blood levels of neopterin and von Willebrand factor antigen. Active vasculitis is associated with inflammation (measured by increased macrophage derived neopterin levels) and/or endothelial cell damage (measured by increased von Willebrand factor antigen). Corticosteroids are the drugs of choice for many pediatric rheumatic diseases, which have a component of vasculitis, but there is controversy concerning the route of administration. The purpose of this study is to ascertain if active vasculitis is associated with decreased bioavailability of absorption of oral prednisolone when compared with values obtained when this substance is given by the intravenous route (methylprednisolone).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 一些结缔组织疾病的儿童的高敏性血管炎的特征是血液水平升高和von Willebrand因子抗原。 活性血管炎与炎症有关（通过巨噬细胞衍生的新近水平增加）和/或内皮细胞损伤（通过增加的von Willebrand因子抗原测量）。 皮质类固醇是许多小儿风湿性疾病的首选药物，它们具有血管炎的成分，但有关给药途径存在争议。 这项研究的目的是确定活性血管炎是否与与静脉内途径（甲基强酮）给出的值相比，与获得该物质获得的值相比，口服泼尼松龙吸收的生物利用度降低有关。