PREDNISONE PHARMACOKINETICS IN JUVENILE DERMATOMYOSITIS
PREDNISONE PHARMACOKINETICS IN JUVENILE DERMATOMYOSITIS
批准号:
7604233
负责人:
LAUREN M. PACHMAN
金额:
$0.27万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-12-01 至 2007-11-30
中文摘要
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
一些患有结缔组织病的儿童的过敏性血管炎的特征是血液中新喋呤和von Willebrand因子抗原水平升高。活动性脉管炎与炎症(通过巨噬细胞衍生的新喋呤水平增加来衡量)和/或内皮细胞损伤(通过von Willebrand因子抗原增加来衡量)有关。皮质类固醇是许多儿童风湿性疾病的首选药物,这些疾病都有血管炎的成分,但关于给药途径存在争议。这项研究的目的是确定活动性脉管炎是否与口服强的松龙吸收的生物利用度降低有关,与静脉给药(甲基强的松龙)所获得的值相比。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Hypersensitivity vasculitis in some children with connective tissue disease is characterized by increased blood levels of neopterin and von Willebrand factor antigen. Active vasculitis is associated with inflammation (measured by increased macrophage derived neopterin levels) and/or endothelial cell damage (measured by increased von Willebrand factor antigen). Corticosteroids are the drugs of choice for many pediatric rheumatic diseases, which have a component of vasculitis, but there is controversy concerning the route of administration. The purpose of this study is to ascertain if active vasculitis is associated with decreased bioavailability of absorption of oral prednisolone when compared with values obtained when this substance is given by the intravenous route (methylprednisolone).
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专著(0)
科研奖励(0)
会议论文
Identical Twins Discordant for Juvenile Dermatomyositis: iPSC-Myogenic Cells
-
批准号:8770388
-
项目类别:
-
资助金额:$20.8万
-
财政年份:2014
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
-
批准号:8152223
-
项目类别:
-
资助金额:$45.58万
-
财政年份:2010
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
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批准号:8074774
-
项目类别:
-
资助金额:$47.63万
-
财政年份:2010
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
-
批准号:8511846
-
项目类别:
-
资助金额:$40.72万
-
财政年份:2010
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
-
批准号:8300031
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项目类别:
-
资助金额:$44.97万
-
财政年份:2010
-
负责人:LAUREN M. PACHMAN
-
依托单位:
JUVENILE DERMATOMYOSITIS: CLINICAL CORRELATES OF VASCULAR DISEASE
-
批准号:7604334
-
项目类别:
-
资助金额:$0.23万
-
财政年份:2006
-
负责人:LAUREN M. PACHMAN
-
依托单位:
JUVENILE DERMATOMYOSITIS: CLINICAL CORRELATES OF VASCULAR DISEASE
-
批准号:7604277
-
项目类别:
-
资助金额:$0.23万
-
财政年份:2006
-
负责人:LAUREN M. PACHMAN
-
依托单位:
JUVENILE DERMATOMYOSITIS: CLINICAL CORRELATES OF VASCULAR DISEASE
-
批准号:7376876
-
项目类别:
-
资助金额:$0.13万
-
财政年份:2005
-
负责人:LAUREN M. PACHMAN
-
依托单位:
PREDNISONE PHARMACOKINETICS IN JUVENILE DERMATOMYOSITIS
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批准号:7376816
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项目类别:
-
资助金额:$1.01万
-
财政年份:2005
-
负责人:LAUREN M. PACHMAN
-
依托单位:
JUVENILE DERMATOMYOSITIS: CLINICAL CORRELATES OF VASCULAR DISEASE
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批准号:7376917
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项目类别:
-
资助金额:$0.13万
-
财政年份:2005
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Untreated DQA1*0501+JDM:Clinical and Genetic Profiles
-
批准号:6641331
-
项目类别:
-
资助金额:$29.29万
-
财政年份:2002
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Untreated DQA1*0501+JDM:Clinical and Genetic Profiles
-
批准号:6924544
-
项目类别:
-
资助金额:$26.41万
-
财政年份:2002
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Untreated DQA1*0501+JDM:Clinical and Genetic Profiles
-
批准号:6766904
-
项目类别:
-
资助金额:$28.94万
-
财政年份:2002
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Untreated DQA1*0501+JDM:Clinical and Genetic Profiles
-
批准号:6544465
-
项目类别:
-
资助金额:$30.34万
-
财政年份:2002
-
负责人:LAUREN M. PACHMAN
-
依托单位:
Untreated DQA1*0501+JDM:Clinical and Genetic Profiles
-
批准号:7103413
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项目类别:
-
资助金额:$25.72万
-
财政年份:2002
-
负责人:LAUREN M. PACHMAN
-
依托单位:
D XYLOSE AND PREDNISONE ABSORPTION IN CHILDREN WITH HYPERSENSITIVITY
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批准号:6275305
-
项目类别:
-
资助金额:$2.26万
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财政年份:1997
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负责人:LAUREN M. PACHMAN
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依托单位:
VASCULOPATHY OF JUVENILE DERMATOMYOSITIS
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批准号:2769640
-
项目类别:
-
资助金额:$19.46万
-
财政年份:1995
-
负责人:LAUREN M. PACHMAN
-
依托单位:
VASCULOPATHY OF JUVENILE DERMATOMYOSITIS
-
批准号:2083725
-
项目类别:
-
资助金额:$14.66万
-
财政年份:1995
-
负责人:LAUREN M. PACHMAN
-
依托单位:
VASCULOPATHY OF JUVENILE DERMATOMYOSITIS
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批准号:2517518
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项目类别:
-
资助金额:$17.1万
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财政年份:1995
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负责人:LAUREN M. PACHMAN
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依托单位:
VASCULOPATHY OF JUVENILE DERMATOMYOSITIS
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批准号:2083724
-
项目类别:
-
资助金额:$15.73万
-
财政年份:1995
-
负责人:LAUREN M. PACHMAN
-
依托单位:
海外基金