PREDNISONE PHARMACOKINETICS IN JUVENILE DERMATOMYOSITIS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 一些患有结缔组织病的儿童的过敏性血管炎的特征是血液中新喋呤和von Willebrand因子抗原水平升高。活动性脉管炎与炎症(通过巨噬细胞衍生的新喋呤水平增加来衡量)和/或内皮细胞损伤(通过von Willebrand因子抗原增加来衡量)有关。皮质类固醇是许多儿童风湿性疾病的首选药物，这些疾病都有血管炎的成分，但关于给药途径存在争议。这项研究的目的是确定活动性脉管炎是否与口服强的松龙吸收的生物利用度降低有关，与静脉给药(甲基强的松龙)所获得的值相比。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypersensitivity vasculitis in some children with connective tissue disease is characterized by increased blood levels of neopterin and von Willebrand factor antigen. Active vasculitis is associated with inflammation (measured by increased macrophage derived neopterin levels) and/or endothelial cell damage (measured by increased von Willebrand factor antigen). Corticosteroids are the drugs of choice for many pediatric rheumatic diseases, which have a component of vasculitis, but there is controversy concerning the route of administration. The purpose of this study is to ascertain if active vasculitis is associated with decreased bioavailability of absorption of oral prednisolone when compared with values obtained when this substance is given by the intravenous route (methylprednisolone).