PREDNISONE PHARMACOKINETICS IN JUVENILE DERMATOMYOSITIS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 某些结缔组织病患儿的超敏性血管炎的特征是血液中新蝶呤和血管性血友病因子抗原水平升高。 活动性血管炎与炎症（通过增加的巨噬细胞衍生的新蝶呤水平测量）和/或内皮细胞损伤（通过增加的血管性血友病因子抗原测量）相关。 皮质类固醇是许多儿科风湿性疾病的首选药物，这些疾病具有血管炎的成分，但关于给药途径存在争议。 本研究的目的是确定活动性血管炎是否与口服泼尼松龙吸收的生物利用度降低有关，与静脉注射（甲泼尼龙）时获得的值相比。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypersensitivity vasculitis in some children with connective tissue disease is characterized by increased blood levels of neopterin and von Willebrand factor antigen. Active vasculitis is associated with inflammation (measured by increased macrophage derived neopterin levels) and/or endothelial cell damage (measured by increased von Willebrand factor antigen). Corticosteroids are the drugs of choice for many pediatric rheumatic diseases, which have a component of vasculitis, but there is controversy concerning the route of administration. The purpose of this study is to ascertain if active vasculitis is associated with decreased bioavailability of absorption of oral prednisolone when compared with values obtained when this substance is given by the intravenous route (methylprednisolone).