UHI COBRE: P3: GROUP A STREPT IN RELATION TO ACUTE RHEUMATIC FEVER IN HAWAII

UHI COBRE：P3：A 组链球菌与夏威夷急性风湿热相关

• 批准号: 7610521
• 负责人: GULIZ ERDEM
• 金额: $ 24.16万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610521
• 关键词: Accounting; Acute; Adhesions; Benign; Child; Computer Retrieval of Information on Scientific Projects Database; Condition; Developed Countries; Developing Countries; Disease; Epidemiologic Factors; Ethnic group; Funding; Grant; Hawaii; Hawaiian population; Heart Diseases; Incidence; Infection; Institution; Invasive; Knowledge; Lead; Molecular Epidemiology; Patients; Polynesian; Property; Range; Rate; Research; Research Personnel; Research Project Grants; Resources; Rheumatic Fever; Serotyping; Skin; Source; Streptococcus pyogenes; Testing; United States National Institutes of Health; expectation; innovation; multiple myeloma M Protein; vaccine development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Infections caused by group A streptococci (GAS) lead to a wide spectrum of diseases, ranging from relatively benign conditions to invasive diseases and serious nonsuppurative sequelae, such as acute rheumatic fever (ARF). While the incidence of ARF has declined dramatically in industrialized countries, ARF remains the leading cause of acquired heart disease among children in many developing countries. For unknown reasons, the annual incidence rate of ARF in Hawaii has continued to be 40-fold higher than that on the continental U.S., particularly among native Hawaiians and other Polynesian ethnic groups. Preliminary studies indicate that pharyngeal infection-associated GAS M protein serotypes (the so-called rheumatogenic types), which are known to be associated with ARF, are infrequently isolated from ARF patients in Hawaii. Instead, unusual M types of GAS have been identified in local patients with ARF or with invasive and non-invasive GAS diseases. The objective of this research project is to determine the molecular epidemiology and adhesion properties of GAS in native Hawaiians and other Polynesian groups. The central hypothesis is that pharyngeal carriage of skin-associated and unusual M types of GAS accounts for high-incidence ARF and other streptococcal diseases in Hawaii. The proposed five-year study will test our hypothesis by pursuing the following specific aims: 1. Characterize the GAS in Hawaii and evaluate the epidemiologic factors that correlate with the high incidence of ARF in native Hawaiians and other Polynesian ethnic groups. 2. Assess the GAS pharyngeal carrier status in different ethnic groups, as well as the adhesion properties of GAS in carriers and patients with ARF and invasive GAS disease in Hawaii. This project is innovative because it will provide new knowledge about the diversity of GAS M proteins and their association with ARF and other streptococcal diseases and their sequelae. Our full expectation at the conclusion of this project is that we will know the diversity of M types in Hawaii. This information will have a significant impact on the development of vaccines for ARF and invasive and non-invasive GAS diseases.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 由A组链球菌（气）引起的感染导致广泛的疾病，从相对良性的疾病到侵入性疾病和严重的非支持性后遗症，例如急性风湿热（ARF）。尽管工业化国家的ARF发生率急剧下降，但ARF仍然是许多发展中国家儿童心脏病的主要原因。由于未知的原因，夏威夷ARF的年度发病率持续比美国大陆的年龄高40倍，尤其是在夏威夷原住民和其他波利尼西亚族群中。初步研究表明，咽部感染相关的气体M蛋白血清型（所谓的风湿性类型）很少与夏威夷的ARF患者分离出来。取而代之的是，在当地的ARF或侵入性和非侵入性气体疾病的当地患者中已经确定了异常的M类型气体。该研究项目的目的是确定夏威夷原住民和其他波利尼西亚群体中气体的分子流行病学和粘附特性。中心假设是，在夏威夷，皮肤相关和不寻常的M类型的咽部与高累积ARF和其他链球菌疾病有关。拟议的五年研究将通过追求以下具体目的来检验我们的假设： 1。表征夏威夷的气体，并评估与夏威夷原住民和其他波利尼西亚族群中ARF高发生率相关的流行病学因素。 2。评估不同种族的气体咽携带者状态，以及夏威夷ARF和ARF和侵入性气体疾病患者气体的粘附特性。 该项目具有创新性，因为它将提供有关气体蛋白质多样性及其与ARF和其他链球菌疾病及其后遗症的新知识。我们在该项目结束时充分的期望是，我们将了解夏威夷M类型的多样性。该信息将对ARF以及侵入性和非侵入性气体疾病的疫苗开发产生重大影响。