PRIMARY GUSTATORY CENTERS IN THE ZEBRAFISH BRAIN

斑马鱼大脑中的主要味觉中心

• 批准号: 7610327
• 负责人: CHARLES F LAMB
• 金额: $ 0.4万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610327
• 关键词: Brain; Complex; Computer Retrieval of Information on Scientific Projects Database; Cyprinidae; Cyprinus carpio; Depth; Development; Dorsal; Face; Facial nerve structure; Fiber; Fishes; Funding; Goldfish; Grant; Institution; Lobe; Motor Neurons; Nerve; Oral cavity; Oropharyngeal; Pharyngeal structure; Research; Research Personnel; Resources; Sensory; Source; Structure; System; Taste Buds; Taste Perception; Travel; United States National Institutes of Health; Zebrafish; base; fish Carp; glossopharyngeal; hindbrain; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Cyprinidae are a group of fishes with highly developed gustatory systems. Most notable among these are the goldfish and carps, which possess elaborate neural structures in the hindbrain that receive gustatory input from numerous taste buds in the oropharyngeal cavity. This sensory input travels through the facial nerve from the rostral oral cavity and through the glossopharyngeal and vagal nerves from the pharynx. The gustatory afferents terminate in highly organized enlargements of the dorsal medulla called the facial, glossopharyngeal, and vagal lobes, respectively. The vagal lobes of these species are not only enlarged, but also are laminated, with sensory input terminating in superficial layers and motor neurons located in deeper layers. Both sensory fibers and motor neurons are organized so that the pharynx is represented topographically in the vagal lobe. We are studying the gustatory system of a less taste-specialized cyprinid, the zebrafish, in order to understand the morphological, functional, and evolutionary bases for the development of complex neural structures.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 鲤科鱼类是一类具有高度发达味觉系统的鱼类。 其中最引人注目的是金鱼和鲤鱼，它们的后脑具有复杂的神经结构，可以接收口咽腔中众多味蕾的味觉输入。 这种感觉输入从口腔头端穿过面神经，从咽部穿过舌咽神经和迷走神经。 味觉传入终止于背髓质高度组织化的扩大部分，分别称为面叶、舌咽叶和迷走神经叶。 这些物种的迷走神经叶不仅增大，而且是分层的，感觉输入终止于浅层，运动神经元位于更深层。 感觉纤维和运动神经元都经过组织，因此咽部在迷走神经叶中以地形形式呈现。 我们正在研究一种味觉不太专业的鲤鱼——斑马鱼的味觉系统，以了解复杂神经结构发育的形态、功能和进化基础。