IDENTIFICATION/CHARACTERIZATION OF VIRUS-INDUCED CELL DEATH GENES IN NICOTIANA

烟草中病毒诱导的细胞死亡基因的鉴定/表征

• 批准号: 7610333
• 负责人: Anthony Cole
• 金额: $ 8.63万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610333
• 关键词: Area; Biotechnology; Cell Death; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Genes; Grant; Institution; Molecular; Molecular Biology; Nicotiana; Pathology; Plant Genes; Plant Viruses; Plants; Proteins; Range; Research; Research Personnel; Resources; Source; Students; Symptoms; System; Tobacco; Tobacco Mosaic Virus; United States National Institutes of Health; Viral; Virus; insight; pathogen; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The characteristic symptoms induced by a plant virus on its host result from the interactions between viral and host gene products. While it has been proven to be relatively easy to identify plant virus genes responsible for symptom development or for host range determination, the mechanisms by which these gene products elicit specific responses or influence host range remain to be fully understood. My research attempts to characterize the viral and plant genes responsible for the hypersensitive response elicited in Nicotiana gossei by Tobacco mosaic virus and the systemic cell death induced in Nicotiana excelsior by Tobacco rattle virus. The information gained from these host-pathogen systems will provide a greater understanding of how these viruses elicit different cell death responses and new insights into the mechanisms of plant virus-induced symptoms. Furthermore, this project exposes undergraduate students to the areas of molecular biology, molecular plant pathology, and the beneficial uses of biotechnology in plant protection.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 植物病毒在宿主上引起的特征性症状是病毒与宿主基因产物之间相互作用的结果。虽然已被证明相对容易识别负责症状发展或宿主范围确定的植物病毒基因，但这些基因产物引起特定反应或影响宿主范围的机制仍有待充分了解。我的研究试图表征与烟草花叶病毒在戈赛烟草中引起的过敏反应以及烟草拨浪鼓病毒在精炼烟草中引起的系统性细胞死亡有关的病毒和植物基因。 从这些宿主-病原体系统获得的信息将有助于更好地了解这些病毒如何引发不同的细胞死亡反应，并为植物病毒引起的症状的机制提供新的见解。此外，该项目还让本科生接触分子生物学、分子植物病理学以及生物技术在植物保护中的有益用途等领域。