CORBE: CENTER FOR PSYCHIATRIC NEUROSCIENCE

描述（由申请人提供）：密西西比大学医学中心（UMMC）的精神神经科学中心（CPN）于四年前通过COBRE拨款启动，已经建立了一个多学科团队，致力于了解抑郁症的病因。该中心现在有潜力发展和维持一个创新的、独立资助的研究中心，专注于抑郁症。该中心及其学术中心——精神病学与人类行为学系的教员，已经报告了突破性的观察结果，发现神经元、神经胶质、脑血管系统、衰老、性别、血清素和谷氨酸在抑郁症病因学中的作用。cobre支持的研究人员通过吸引外部资金和在神经科学的主要期刊上发表文章，提高了他们的竞争力。该中心将继续为初级和中级研究人员提供一个良好的环境，通过与领先的国家中心和研究抑郁症的科学家密切合作，开展基于这些对抑郁症病理生理学的新见解的拟议项目。为了实现建立一个专注于抑郁症的创新和多学科中心的目标，提出了以下具体目标：目标1是增强四名研究人员的竞争性独立研究经费，详见研究提案。此外，抑郁症领域的主要外部和内部科学家将继续在基础和临床神经科学方面指导所有中心教员。目标2是继续扩大研究资源，以开发创新的抑郁症相关项目。实现这一目标的核心设施将包括：a)死后人类大脑收集，b)专注于抑郁症及其治疗相关行为研究的动物大脑收集，c)细胞水平定量脑生物学研究的成像设施，以及(d)实施分子生物学技术的资源。目标3是通过尖端技术的培训，继续师资队伍的发展和新的神经科学研究者的成长，并为中心教师指导的本科生和研究生提供神经科学方面的研究机会。目标4是赞助一个竞争性的小额资助项目，以推进与提案中概述的主题相关的抑郁症研究。对抑郁症的关注、研究综合模型的项目、优秀的中心教师、培训机会、小额赠款计划和UMMC管理部门的慷慨支持，将确保一个创新和多学科的研究中心的持续发展，并朝着独立资助的方向大力发展，并发展一支核心的高级和新的神经科学教师队伍。

DESCRIPTION (provided by applicant): The Center for Psychiatric Neuroscience (CPN) at The University of Mississippi Medical Center (UMMC), initiated four years ago through a COBRE grant, has developed a multidisciplinary team committed to understanding the etiology of depression. The center now has the potential to develop and sustain an innovative and independently funded research center focused on depression. Faculty in the Center and its academic home, the Department of Psychiatry & Human Behavior, have already reported groundbreaking observations on the roles of neurons, glia, cerebral vasculature, aging, gender, serotonin and glutamate in the etiology of depression. COBRE-supported investigators have increased their competitiveness by attracting extramural funds and publishing in leading journals of neuroscience. The Center will continue to provide an excellent environment for junior and mid-level investigators by working in close collaboration with leading national centers and scientists studying depression to carry out the proposed projects that build on these novel insights into the pathophysiology of depression. To achieve the goal of establishing an innovative and multidisciplinary Center focused on depression, the following Specific Aims are proposed: Aim 1 is to enhance the competitive independent research funding of four investigators, as detailed in research proposals. In addition, leading external and internal scientists in depression will continue to mentor all Center faculty in basic and clinical neuroscience. Aim 2 is to continue the expansion of research resources for the development of innovative depression related projects. Core facilities to accomplish this will include: a) a postmortem human brain collection, b) an animal brain collection focused on behavioral studies related to depression and its treatment, c) imaging facilities for studying quantitative brain biology at the cellular level, and (d) resources for the implementation of molecular biological techniques. Aim 3 is to continue faculty development and growth of new neuroscience investigators through training in cutting-edge technologies and to promote research opportunities in neuroscience for undergraduate and graduate students being mentored by Center faculty. Aim 4 is to sponsor a competitive small grant program that advances research in depression related to the themes outlined in the proposal. The focus on depression, projects examining integrated models, an outstanding Center faculty, training opportunities, a small grant program and generous support by the UMMC administration will ensure the continued growth of a research center that is innovative and multidisciplinary, and moving strongly toward independent funding, and development of a core of senior and new neuroscience faculty.