Task Specific Project 1

任务具体项目 1

• 批准号: 7728714
• 负责人: Brian D. Ross
• 金额: $ 5.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-29 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7728714
• 关键词: Animals; Antigens; Binding; Biology; CDX2 gene; Clinic; Clinical; Colon; Colon Carcinoma; Colonoscopy; Consumption; Crohn' s disease; Detection; Development; Diagnostic Imaging; Disease model; Distal; Endoscopy; Engineering; Evaluation; Feces; Frequencies; Genus Cola; Image; Label; Lead; Malignant Neoplasms; Methods; Molecular; Monitoring for Recurrence; Muscle Cramp; Neoplasms; Outcome; PET/CT scan; Pain; Patient Care; Patients; Peptides; Polyethylene Glycols; Population; Preparation; Procedures; Process; Radiolabeled; Recording of previous events; Reporter; Risk; Screening procedure; Specificity; Syndrome; Techniques; Therapeutic; Time; Translations; Ulcerative Colitis; Validation; colon dysplasia; cost; experience; improved; in vivo; molecular/cellular imaging; mouse model; neoplastic; novel; pre-clinical; radioligand; radiotracer; response; tool; tumor

Screening for colon cancer requires preparation in the form of consumption of a large volume (usually at least 4 L) of polyethylene glycol (golytely) to clear the colon of stool and debris. Patients usually find this process to be unpleasant, and also experience pain, discomfort, and cramping on the ensuing colonoscopy procedure. Those who are at high risk, such as history of ulcerative colitis, Crohn's disease, and familial syndromes are required to undergo a colonoscopy annually. Methods that can accurately assess the colon for the presence of colonic dysplasia in this population may reduce the frequency or extend the interval in between these procedures, thus saving time, cost, and patient inconvenience. The development of novel techniques for in vivo molecular and cellular imaging in the pre-clinical and clinical setting, particularly those that have molecular specificity for neoplastic antigens, could have significant implications for the detection of neoplasia in the colon, identification of malignancy recurrence and monitoring of therapeutic response. The increased availability of clinical SPECT/CT and PET/CT scanners can facilitate the translation of new tumor imaging radioligands to the clinic. The successful outcome of this Project will provide new tools that should lead to important pre-clinical opportunities to further understand the biology and treatment response of genetically engineered models of this disease. Successful validation of these novel reporter probes will provide for new clinical diagnostic imaging capabilities that may lead to improved patient care by assessing those at high risk for the appropriate timing of colonoscopy procedures.

结肠癌的筛查需要以大量消费的形式进行准备（通常至少至少 4 L）聚乙烯乙二醇（糖）清除粪便和碎屑的结肠。患者通常会发现这个过程 保持不愉快，并且在随后的结肠镜检查过程中也会感到疼痛，不适和痉挛。 那些处于高风险的人，例如溃疡性结肠炎史，克罗恩病和家族综合症的史 要求每年进行结肠镜检查。可以准确评估结肠的方法 该人群中的结肠发育不良可能会降低频率或扩展这些间隔 程序，从而节省时间，成本和患者不便。用于IN新颖技术的开发 在临床和临床环境中，体内分子和细胞成像，尤其是那些具有分子的人 肿瘤抗原的特异性可能会对在结肠中检测肿瘤的检测具有显着影响， 鉴定恶性复发和治疗反应的监测。增加的可用性 临床SPECT/CT和PET/CT扫描仪可以促进将新肿瘤成像放射性物的转化为 诊所。该项目的成功结果将提供新工具，应导致重要的临床前 进一步了解基因工程模型的生物学和治疗反应的机会 疾病。这些新型记者探针的成功验证将提供新的临床诊断成像 通过评估适当时机的高风险的能力可能会改善患者护理的能力 结肠镜检查程序。