AGING, VASCULAR DISEASE AND COGNITION

衰老、血管疾病和认知

• 批准号: 7604816
• 负责人: DAVID J MOSER
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604816
• 关键词: Aging; Atherosclerosis; Attenuated; Blood Vessels; Cognition; Computer Retrieval of Information on Scientific Projects Database; Developed Countries; Elderly; Functional disorder; Funding; Goals; Grant; Health; Impaired cognition; Individual; Inferior; Institution; Longitudinal Studies; Morbidity - disease rate; Neurocognitive; Performance; Process; Research; Research Personnel; Research Project Grants; Resources; Risk; Source; Time; United States National Institutes of Health; Vascular Diseases; mortality; prevent; therapy development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Atherosclerotic vascular disease (AVD) is the leading cause of mortality and morbidity in most industrialized nations and is a primary contributor to cognitive decline in the elderly. Despite this, there are very few longitudinal studies of AVD-related cognitive decline and the factors that are most predictive of this process. The identification of individuals who are at greatest risk for such decline will have significant implications for the development of interventions to prevent or attenuate this important health problem. This research project will allow the investigators to meet the following short-term scientific goals: 1) determine whether elderly individuals with atherosclerotic vascular disease demonstrate inferior baseline neurocognitive performance and greater neurocognitive decline across time, as compared to healthy controls; and 2) determine whether degree of endothelial dysfunction and/or other vascular illness-related variables can be used to identify subjects at greatest risk for neurocognitive decline.

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