AGING, VASCULAR DISEASE AND COGNITION

衰老、血管疾病和认知

• 批准号: 7377006
• 负责人: DAVID J MOSER
• 金额: $ 1.16万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377006
• 关键词: AGING; VASCULAR; DISEASE; COGNITION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Atherosclerotic vascular disease (AVD) is the leading cause of mortality and morbidity in most industrialized nations and is a primary contributor to cognitive decline in the elderly. Despite this, there are very few longitudinal studies of AVD-related cognitive decline and the factors that are most predictive of this process. The identification of individuals who are at greatest risk for such decline will have significant implications for the development of interventions to prevent or attenuate this important health problem. This research project will allow the investigators to meet the following short-term scientific goals: 1) determine whether elderly individuals with atherosclerotic vascular disease demonstrate inferior baseline neurocognitive performance and greater neurocognitive decline across time, as compared to healthy controls; and 2) determine whether degree of endothelial dysfunction and/or other vascular illness-related variables can be used to identify subjects at greatest risk for neurocognitive decline.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。动脉粥样硬化性血管疾病（AVD）是大多数工业化国家死亡率和发病率的主要原因，也是老年人认知能力下降的主要原因。尽管如此，很少有关于AVD相关认知下降的纵向研究以及最能预测这一过程的因素。确定最有可能出现这种下降的个人，将对制定预防或减轻这一重要健康问题的干预措施产生重大影响。该研究项目将使研究人员能够满足以下短期科学目标：1）确定与健康对照组相比，患有动脉粥样硬化性血管疾病的老年人是否表现出较低的基线神经认知表现和随时间推移更大的神经认知下降;和2）确定内皮功能障碍和/或其它血管疾病的程度-相关变量可用于识别神经认知能力下降风险最大的受试者。