GENETIC DETERMINANTS OF PELVIC FLOOR DISORDERS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 骨盆底疾病，包括盆腔器官脱垂和尿失禁，是常见的问题，在所有年龄段。 每九名女性中就有一名在其一生中会因这些疾病接受手术，三分之一的女性会因骨盆底疾病接受多次手术。 更多的妇女受到脱垂和失禁的影响，但无需手术即可控制症状。 虽然尿失禁和盆腔器官脱垂是不同的条件，他们经常发生在同一个人。 这可能是因为他们有一些共同的风险因素，如分娩，但骨盆底疾病的原因通常是未知的。 本研究的目的是确定遗传因素是否影响骨盆底疾病的发展。 这一点很重要，原因有两个：它可能有助于发现这些疾病的原因，它可能有助于我们识别处于危险中的妇女，并在问题发展之前加以预防。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pelvic floor disorder, including pelvic organ prolapse and urinary incontinence, are common problems seen in all ages. One of every nine women will undergo surgery for these disorders in her lifetime, and one-third will undergo repeated surgeries for pelvic floor disorders. Many more women are affected by prolapse and incontinence but manage their symptoms without surgery. Although urinary incontinence and pelvic organ prolapse are distinct conditions, they frequently occur in the same individual. This may because they share some risk factors such as childbirth, but the causes of pelvic floor disorders is generally unknown. The purpose of this study is to determine if genetic factors influence the development of pelvic floor disorders. This is important for two reasons: it might help to discover the cause of these conditions, and it might help us to identify women at risk and prevent the problem before it develops.