GENETIC DETERMINANTS OF PELVIC FLOOR DISORDERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 盆底疾病，包括盆腔器官脱垂和尿失禁，是所有年龄段的常见问题。每九名女性中就有一名在有生之年接受过这些疾病的手术，三分之一的女性将因盆底疾病反复接受手术。更多的女性受到脱垂和大小便失禁的影响，但不需要手术就能控制自己的症状。虽然尿失禁和盆腔器官脱垂是不同的情况，但它们经常发生在同一个人身上。这可能是因为他们有一些共同的风险因素，如分娩，但盆底疾病的原因通常是未知的。 这项研究的目的是确定遗传因素是否影响盆底疾病的发展。这一点很重要，有两个原因：它可能有助于发现这些疾病的原因，它可能有助于我们识别处于风险中的女性，并在问题发展之前预防它。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pelvic floor disorder, including pelvic organ prolapse and urinary incontinence, are common problems seen in all ages. One of every nine women will undergo surgery for these disorders in her lifetime, and one-third will undergo repeated surgeries for pelvic floor disorders. Many more women are affected by prolapse and incontinence but manage their symptoms without surgery. Although urinary incontinence and pelvic organ prolapse are distinct conditions, they frequently occur in the same individual. This may because they share some risk factors such as childbirth, but the causes of pelvic floor disorders is generally unknown. The purpose of this study is to determine if genetic factors influence the development of pelvic floor disorders. This is important for two reasons: it might help to discover the cause of these conditions, and it might help us to identify women at risk and prevent the problem before it develops.