THE MARKERS OF HEALTHY AGING STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对虚弱老年人的评估、治疗和康复是老年医学的基石。大多数研究和我们的初步数据支持这一概念，即虚弱的人是老年人中最脆弱的一组，与年龄匹配的非虚弱的人相比，发病率、死亡率和功能衰退的发生率明显更高。随着越来越多的美国人活到80岁的S和90岁的S，对于研究人员和临床医生来说，了解虚弱的生理基础和残疾的演变将是至关重要的，以便识别处于危险中的个人，并促进改进预防和治疗。在过去的几年里，一些论文已经确定了免疫学和内分泌因素，这些因素表明在虚弱和残疾中起到了作用。这项研究的目的和意义是确定在WHAS II纵向研究中可能预测脆弱性的生物学相关因素。通过纵向数据收集和分析，我们可能也能够确定这些过程中的因果路径。为了实现这一点，我们将检测促炎和抗炎细胞因子，包括IL-6、干扰素-γ、IL-10和肿瘤坏死因子-α，以及被认为在这些过程的演变中起重要作用的任何其他细胞因子。此外，还将测量脱氢表雄酮-S、胰岛素样生长因子-1、唾液皮质醇、雌二醇和睾酮等激素，并将其与虚弱、残疾和死亡等不良健康后果相关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The evaluation, treatment, and rehabilitation of frail older adults is a cornerstone of geriatric medicine. Most studies and our preliminary data support the concept that frail individuals are the most vulnerable subset of older adults, with significantly higher rates of morbidity, mortality, and functional decline as compared to age-matched individuals who are not frail. As increasing numbers of Americans live into their 80's and 90's, it will be of critical importance for investigators and clinicians to understand the physiologic basis of frailty and the evolution of disability in order to identify individuals at risk and to facilitate improved prevention and treatment. In the past several years, a number of papers have identified immunologic and endocrine factors that suggest a role in frailty and disability. The purpose and significance of this study is to identify the biologic correlates that may predict frailty in the WHAS II longitudinal study. Through longitudinal data collection and analyses, we may be able to identify causal pathways in these processes as well. In order to accomplish this, we will measure pro and anti- inflammatory cytokines, including IL-6, IFN-gamma, IL-10, and TNF-alpha in addition to any other cytokine deemed important in the evolution of these processes. In addition, hormones such as DHEA-S, IGF-1, salivary cortisol, estradiole, and testosterone will be measured and correlated with the adverse health outcomes of frailty, disability, and mortality.