FISH OIL TO MAINTAIN WEIGHT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本申请中提出的这项研究主要寻求确定在任何与疾病相关的体重减轻(恶病质)中，添加鱼油的营养补充剂是否可以保持体重。维持体重的干预措施虽然不是为了立即消除肿块，但可能会影响患者的临床状态。这无疑将有助于提高患者的生活质量，并可能有助于提高对潜在肿瘤治疗的耐受性。第二个目的是了解性激素水平和体重在恶病质患者中的作用，目标是在未来的研究中可能测试一种常用的营养补充剂(DHEA)，以获得鱼油的附加效应。这项研究还将试图通过使用约翰·霍普金斯癌症补充和替代医学中心内建立的复杂的CAM中心实验室核心来阐明鱼油的作用机制。此外，随着公众广泛使用营养补充剂，为了制定标准，营养补充剂的临床试验是一项非常紧迫的公共卫生需求。虽然临床试验中的应计是一项挑战，但在约翰霍普金斯大学与胰腺癌临床团队的合作下，我们确信有足够的应计成果来回答我们的问题，并提高对胰腺癌患者体重维持的整体理解。 从这项建议中获得的信息将扩大我们对在治疗恶病质并发症中使用膳食补充剂的理解。此外，我们将获得信息，以更好地了解癌症浪费本身。有了这项研究的信息，我们将更好地评估其他潜在的CAM治疗癌症浪费的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study proposed in this application primarily seeks to determine if nutritional supplementation with fish oils can maintain weight in any disease-related weight loss (cachexia). An intervention to maintain weight, although not aimed at achieving immediate eradication of the tumor mass, could influence the course of the patient's clinical state. This would no doubt contribute to improving the patients' quality of life and possibly tolerance to treatment of the underlying tumor. A secondary purpose is to understand the role of sex hormone levels and weight in cachexia patients with a goal of possibly testing a commonly used nutritional supplement (DHEA) in future studies to gain an additive effect on fish oils. This study will also attempt to elucidate the mechanism of action of fish oils through use of the sophisticated CAM Center laboratory cores established within the Johns Hopkins Center for Complementary and Alternative Medicine in Cancer. Furthermore, with the wide use of nutritional supplements by the public, clinical trials of nutritional supplements are a very urgent public health necessity in order to set the standard. Although accrual in clinical trials is a challenge, at Johns Hopkins with the collaboration of the pancreatic cancer clinic team, we are certain of adequate accrual to answer our question and to improve the overall understanding of weight maintenance in pancreatic cancer patients. Information obtained from this proposal will expand our understanding of the use of dietary supplements in the treatment of complications of cachexia. In addition, we will obtain information to better understand cancer wasting itself. With information from this investigation, we will be better positioned to evaluate other potential CAM therapies for cancer wasting.