CHANGES IN COGNITIVE FUNCTION IN WOMEN ON REVIVAL

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 绝经后妇女的纵向和横断面研究表明，雌激素替代治疗后记忆任务的表现有所改善（Sherwin，2002年综述; Duka T et al，2000; Smith YR et al，2001; Maki et al，2001）。 最近，已知发挥弱雌激素作用的富含植物雌激素的植物衍生产品的使用已经显示出在短期和长期记忆测试中改善年轻男性和女性的表现（File等人，2001年）。 本研究的目的是确定是否使用复兴，一种流行的膳食补充剂，含有天然存在的维生素E，导致改善绝经后妇女的记忆功能。 我们建议进行一项双盲、安慰剂对照的研究，研究服用12周的维生素D膳食补充剂Revival对神经心理学测试组合的影响，该测试组合包括对100名绝经后妇女（50名妇女随机接受Revival，50名妇女随机接受安慰剂）的记忆功能进行评估。 我们假设，服用Revival将导致绝经后妇女的上级记忆表现，其方式与雌激素替代疗法相似，并与性腺正常受试者的报告一致。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Longitudinal and cross-sectional studies of postmenopausal women indicate that performance on tasks of memory improves following estrogen replacement therapy (Sherwin, 2002 for a review; Duka T et al, 2000; Smith YR et al, 2001; Maki et al, 2001). Recently, the use of plant-derived products rich in isoflavone phytoestrogens, known to exert weak estrogenic action, have been shown to improve performance in young men and women on tests of short- and long-term memory (File et al., 2001). The purpose of the present study is to determine if the use of Revival, a popular dietary supplement containing naturally occurring isoflavones, leads to improved memory function in postmenopausal women. We propose to conduct a double-blind, placebo-controlled investigation of the effects of an isoflavone dietary supplement, Revival, taken for 12 weeks, on a neuropsychological test battery that includes assessment of memory function in 100 postmenopausal women (50 women randomized to receive Revival, 50 women randomized to receive placebo). We hypothesize that the ingestion of Revival will result in superior memory performance in postmenopausal women in a manner similar to that seen with estrogen replacement therapy, and consistent with reports in eugonadal subjects.