A PROSPECTIVE DATABASE OF INFANTS WITH CHOLESTASIS

胆汁淤积婴儿的前瞻性数据库

• 批准号: 7604737
• 负责人: KATHLEEN SCHWARZ
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604737
• 关键词: Biliary Atresia; Blood; Child; Cholestasis; Clinical; Computer Retrieval of Information on Scientific Projects Database; Databases; Funding; Gene Proteins; Genomics; Grant; Infant; Institution; Liver; Liver diseases; Natural History; Neonatal; Pathogenesis; Pattern; Plasma; Proteomics; Research; Research Personnel; Resources; Source; Specimen; Techniques; Tissue Sample; Tissues; United States National Institutes of Health; Viral; neonatal hepatitis; prospective; protein expression; repository; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this research study are to establish (1) a database containing clinical information and (2) a repository of blood and tissue samples from children with neonatal liver disease such as biliary atresia and neonatal hepatitis to facilitate research in these important liver problems in children. Examples of the use of this database and repository are to study the pathogenesis and natural history of biliary atresia and neonatal hepatitis or to evaluate patterns of cellular gene and protein expression in tissue specimens and plasma by viral, genomic and proteomic techniques.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是建立（1）包含临床信息的数据库和（2）来自新生儿肝病（如胆道闭锁和新生儿肝炎）儿童的血液和组织样本库，以促进对这些重要儿童肝脏问题的研究。 使用该数据库和知识库的例子是研究胆道闭锁和新生儿肝炎的发病机制和自然史，或通过病毒、基因组和蛋白质组学技术评估组织标本和血浆中细胞基因和蛋白质表达的模式。