Modulation of leishmaniasis by the proinflammatory cytokines TNF

促炎细胞因子 TNF 对利什曼病的调节

• 批准号: nhmrc : 485807
• 负责人: Prof Heinrich Korner
• 金额: $ 19.26万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-leishmaniasis-proinflammatory-cytokines-tnf/78359
• 关键词: Modulation; leishmaniasis; proinflammatory; cytokines; TNF

We have established a mouse model that has been genetically modified and cannot produce the cytokine tumour necrosis factor. This cytokine is secreted in the beginning of the inflammatory response. If these mice are infected with a parasite they are not able to heal the infection and die quickly. We can demonstrate that these mice cannot regulate the beginning inflammatory response and do not form a cellular infiltrate at the site of infection.

我们已经建立了一个转基因小鼠模型，不能产生细胞因子肿瘤坏死因子。这种细胞因子在炎症反应开始时分泌。如果这些小鼠感染了寄生虫，它们无法治愈感染并迅速死亡。我们可以证明，这些小鼠不能调节开始的炎症反应，也不能在感染部位形成细胞浸润。