Biological function of the chemokine receptor 6 expression on B cells

B 细胞上趋化因子受体 6 表达的生物学功能

• 批准号: nhmrc : 329210
• 负责人: Prof Heinrich Korner
• 金额: $ 16.1万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biological-function-chemokine-b-cells/82473
• 关键词: Biological; function; chemokine; receptor; expression

The correct movement of cells is important for the defence of the body against micro-organisms. White blood cells have to arrive quickly at the site of an infection and information about this infection has to be spread. White blood cells that navigate the body are using molecules on their surface termed as receptors which help them to detect the scent of their target. One of these receptors is located on white blood cells that produce antibodies and enables these cells to migrate to appropriate tissues . We want to know more about the biological role of this receptor and its functions during the immune response to pathogens. It would be of significant importance to understand the impact of these cell surface receptors in detail because this could open the possibility to new therapies of infectious diseases and chronic inflammation.

细胞的正确运动对于身体防御微生物是重要的。白色血细胞必须迅速到达感染部位，有关这种感染的信息必须传播。白色血细胞在身体中导航，它们使用表面上的分子作为受体，帮助它们探测目标的气味。这些受体之一位于产生抗体的白色血细胞上，使这些细胞能够迁移到适当的组织。我们想知道更多关于这种受体的生物学作用及其在对病原体的免疫反应中的功能。详细了解这些细胞表面受体的影响将具有重要意义，因为这可能为感染性疾病和慢性炎症的新疗法开辟可能性。