Multidisciplinary Training in Translational Cardiovascular Research

描述（由申请人提供）： 本申请要求为转化心血管研究的多学科培训提供博士前和博士后资金。哥伦比亚大学医学中心的转化心血管研究培训计划旨在加强和确保心血管科学家的发展，他们在心血管细胞生物学，生物物理学，遗传学和基因组学，生物和组织工程以及临床科学领域拥有广泛的知识。培训将在哥伦比亚大学内科与外科学院的克莱德和海伦吴分子心脏病学中心、生理学和细胞生物物理学系以及包括NIH路线图功能基因组学高通量筛选中心的朱迪思苏兹伯格基因组中心进行。通过为纽约市大学本科生设立的少数群体研究金方案，特别强调多样性，该方案为服务不足的少数群体提供了一个渠道，使他们能够在哥伦比亚大学的心血管训练方案中接受培训。分子心脏病学中心的成员包括基础和翻译研究人员，他们的主要任命是在医学，药理学，生理学和细胞生物物理学部门。该中心和生理学系拥有完善的心血管研讨会系列和期刊俱乐部，联合实验室会议和务虚会，旨在鼓励合作并促进心血管研究的卓越。基础和转化心血管生物学课程将基础心血管分子生理学与转化心血管生物学联系起来。受训人员将接触到不同的教师群体，包括外部机构和制药行业的几个教师，他们将在遗传学，细胞成像，高通量筛选等特定领域提供短期有针对性的指导，如果他们在一个实验室或一个机构接受培训，这是不可能的。该计划将采用跨学科的方法，特别强调前瞻性思维科学，包括功能基因组学，化学生物学，结构生物学，组织工程，生物工程和分子生理学，所有这些都是在由一些世界领先的心血管科学家领导的心血管实验室的背景下进行的。

DESCRIPTION (provided by applicant): This application requests pre-doctoral and post-doctoral funding for Multidisciplinary Training in Translational Cardiovascular Research. The training program in Translational Cardiovascular Research at Columbia University Medical Center is conceived to enhance and ensure the development of cardiovascular scientists who have broadly-based knowledge in the fields of Cardiovascular Cell Biology, Biophysics, Genetics and Genomics, Bio- and Tissue-Engineering and Clinical Sciences. The training will be based within the Clyde and Helen Wu Center for Molecular Cardiology and Department of Physiology and Cellular Biophysics at Columbia University College of Physicians & Surgeons, and the Judith Sulzberger Genome Center which includes an NIH Roadmap Functional Genomics High Throughput screening center. Particular emphasis has been placed on diversity through a Minority Research Fellowship Program for undergraduates in New York City Universities that serves as a pipeline for underserved minorities to train in the cardiovascular training program at Columbia. Members of the Center for Molecular Cardiology include basic and translational researchers whose primary appointments are within the Departments of Medicine, Pharmacology, and Physiology and Cellular Biophysics. The Center and the Department of Physiology have well-established cardiovascular seminar series and journal clubs, joint laboratory meetings, and retreats, that are designed to encourage collaborations and foster excellence in cardiovascular research. A course in basic and translational cardiovascular biology bridges fundamental cardiovascular molecular physiology with translational cardiovascular biology. Trainees will be exposed to a diverse group of faculty, including several at outside institutions and in the pharmaceutical industry who will provided short-term targeted mentoring in specific areas such as genetics, cell imaging, high throughput screening, which would not be possible if they trained in a single laboratory or at one institution. The proposed program will use an interdisciplinary approach with special emphasis on forward thinking science including functional genomics, chemical biology, structural biology, tissue engineering, bioengineering and molecular physiology all in the context of established cardiovascular laboratories headed by some of the world's leading cardiovascular scientists.