Training in Cardiovascular Translational Research

描述（由申请人提供）：本申请申请博士预科（4个名额）和博士后（4个名额）培训资助，题为“心血管转化研究培训”。这项培训资助申请是专门为培养未来的CV科学家而设计的，这些科学家将通过开发新的治疗方法，将实验室的基本发现带入临床实践。该培训项目的关键创新是一个为期三个学期的纵向课程，涵盖了成功发现、验证和开发治疗方法所需的主要学科，包括：1)心血管疾病的基本机制/靶点识别；2)给药靶点/高通量筛选；3)利用人类疾病的相关动物模型进行靶点验证/概念证明；4)药物化学导论-化合物/生物制剂的优化；5)知识产权保护的基本概念；6)医学药理学基础；毒理学基础知识；7)药物开发从临床前到IND申请的主要内容；8)临床试验基础指导教师将指导四个主要领域的研究培训：1)CV信号分子结构生物学，包括离子通道和g蛋白偶联受体的结构解决；2)心血管细胞信号传导的生物物理学，包括离子通道、心脏和平滑肌信号传导；3)心血管疾病动物模型，包括心力衰竭、心律失常、动脉粥样硬化、糖尿病小鼠模型；4)临床-转化心血管科学，包括综合利用人类干细胞、心血管疾病遗传学、生物材料支架和生物反应器、临床电生理学和心力衰竭。重点是培养具有广泛基础、跨学科知识和独特技能的科学家

DESCRIPTION (provided by applicant): This application requests funding for a pre-doctoral (4 slots) and post-doctoral (4 slots) training grant entitled, 'Training in Cardiovascular Translationl Research'. This training grant application is uniquely designed to train future CV scientists who will have expertise in bringing basic discoveries from the laboratory into clinical practice throug development of novel therapeutics. The KEY INNOVATION in the is training program is a longitudinal course over three semesters that covers the major disciplines required for successful therapeutics discovery, validation and development including: 1) basic mechanisms in CV diseases/target identification; 2) drugging the target/high throughput screening; 3) target validation/proof of concept using relevant animal models of human disease; 4) introduction to medicinal chemistry - optimization of compounds/biologicals; 5) basic concepts of intellectual property protection; 6) fundamentals of medical pharmacology; 6) basics in toxicology; 7) principals of drug development from pre-clinical to IND filing; 8) fundamentals of clinical testing Faculty mentors will direct research training in four primary areas: 1) Structural Biology of CV Signaling Molecules, including solving structures of ion channels and G-protein coupled receptors; 2) Biophysics of CV Cell Signaling, including ion channels, cardiac and smooth muscle signaling; 3) Animal Models of CV Diseases, including mice models of heart failure, cardiac arrhythmias, atherosclerosis, and diabetes; and 4) Clinical-Translational CV Sciences, including integrated use of human stem cells, genetics of cardiovascular diseases, biomaterial scaffolds and bioreactors, clinical electrophysiology, and heart failure. Strong emphasis is given to training scientists with broadly- based, interdisciplinary knowledge and unique skill sets, with a strong fundamental understanding of cardiovascular biology and physiology. The usual duration for support on the training grant is two years, although individuals may be enrolled in the training program for up to five years. Training-grant-supported trainees will be expected and counseled to apply for independent funding to continue their training after two years of grant support. Pre-doctoral candidates are selected from a very large pool of outstanding applicants to 4 graduate programs at Columbia University Medical Center- Cellular Physiology and Biophysics, Integrated Program, Nutritional and Metabolic Biology, Pharmacology and Molecular Signaling. Post-doctoral candidates are likewise selected from a large applicant pool made up of direct applications to program faculty and the training program, as well as respondents to advertisements in scientific journals. Special efforts are undertaken to enhance the recruitment of woman and minorities. The training program and the core departments have well-established cardiovascular seminar series and journal clubs, joint laboratory meetings and retreats that are designed to foster collaborations and interdisciplinary research. In addition, th training program itself sponsors an annual retreat, seminars and work-in-progress sessions to assess trainee progress. The training program has an efficient evaluation and feedback system to ensure appropriate training of our pre-doctoral students and post-doctoral fellows. Throughout the program and afterwards, trainees are advised on research and career development, individually and through a mentoring program headed by an Associate Director for Trainee Development. The program is designed to take advantage of the many existing strengths of Columbia University, including the Irving Center for Clinical and Translational Research (CTSA), Mailman School of Public Health, Genome Center, Bioinformatics, Tissue and Biomedical Engineering and numerous basic science departments and strong clinical programs.