Institutional Training Grant in the Genomic Sciences

描述（由申请人提供）：基因组科学培训计划（GSTP）正在帮助培养新一代的基因组科学家，他们具有跨多个学科的优势。这里提出的研究培训机会的主要动机是基于快速增长的一系列重要的生物学和遗传学问题，这些问题现在可以得到解决，因为新技术可以生成和解释越来越复杂的数据集，从而阐明丰富的基因组数据。生物学研究的新的基因组方法要求科学家在几个领域都有知识和技能，有效地促进新的见解或发明。因此，全球优惠制的重点是开发新的工具，以创建和解释大规模的实验性努力，将来自多个领域的调查方法进行教学性交织（生物学、遗传学、物理科学、工程学、计算机科学和统计学），这些学科被单独勾画出来，以补充受训者的核心学科重点，但它是建立在基因组科学的成就和知识之上的。鉴于威斯康星州大学令人难以置信的丰富的科学和工程跨度，GSTP能够招募优秀的学员谁大大先进的质谱，微阵列技术，生物设备，并创造了新的应用程序，利用这些优势的尖端研究到蛋白质组学，转录，代谢组学和基因组生物学。这些突破性的发展推动了许多学员和培训师成为跨部门，中心和其他培训计划的重要合作的“磁铁”。我们建议，为了延长这一方案，我们继续把重点放在全面贸易优惠制的方案评价上，并更多地接受统一汇率机制的受训人员。我们要求每年培训资金：10名博士前（1-3年），4名博士后（1 -3年）和2名短期（0.25年）学员;我们将寻求最近的本科和研究生学位的学员。现代医学实践越来越依赖于基因组研究的成果，用于新的诊断，药物和其他疗法。我们建议培训科学家，他们将开发系统，使生物医学研究人员和公众能够更多地使用基因组信息。

DESCRIPTION (provided by applicant): The Genomic Sciences Training Program (GSTP) is helping to produce the new generation of genomic scientists with strengths spanning multiple disciplines. The primary motivation for the research training opportunities proposed here is predicated on the rapidly growing set of significant biological and genetics-based questions that can now be addressed given the wealth of genomic data elucidated by new technologies that generate and interpret increasingly complex data sets. The new genomic approaches to biological investigation demand scientists who are knowledgeable and skilled across several fields in effective ways that potentiate new insights or inventions. Accordingly, the development of new tools for the creation and interpretation of large-scale experimental efforts is what GSTP has focused on by the didactical interweaving of investigative approaches drawn from multiple fields (biology, genetics, physical sciences, engineering, computer science, and statistics) that were individually contoured for complementing a trainee's core disciplinary focus, yet built upon achievement and knowledge within the genomic sciences. Given the incredibly rich scientific and engineering span of the University of Wisconsin, GSTP was able to recruit outstanding trainees who greatly advanced mass spectroscopy, microarray technology, bio-devices, and created new applications exploiting these advantages for cutting-edge investigation into proteomics, transcription, metabolomics, and genome biology. These groundbreaking developments have propelled many trainees and trainers to become "magnets" for significant collaborations reaching across departments, centers, and other training programs. We propose that for the renewal of this program that we continue this focus with added emphasis on programmatic evaluation of GSTP and increased embracement of URM trainees. We request funding for training on a yearly basis: 10 predoctoral (1-3 yrs), 4 postdoctoral (1-3 yrs), and 2 short-term (0.25 yr) trainees; we will seek trainees with recent undergraduate and graduate degrees. Modern medical practice is increasingly relying on the fruits of genomic research for new diagnostics, drugs, and other therapies. We propose to train scientists who will be developing the systems that will enable greater use of genomic information for biomedical researchers and the general public.