Institutional Training in the Genomic Sciences

描述(由申请人提供)：基因组科学培训计划(GSTP)正在培训具有跨多个学科优势的新一代基因组科学家。我们提出的培训机会和环境将使我们的受训人员能够开发和应用新的工具，这些工具源于技术进步，而这些技术进步得益于使各种大型数据集发挥作用的尖端统计和计算方法。生物和医学研究的新基因组方法要求科学家在几个领域都有知识和技能，并以有效的方式激发新的见解或发明。因此，能够创建和解释大规模实验工作的新工具的出现是GSTP通过教学交织来自多个领域(生物学、遗传学、物理科学、工程学、计算机科学和统计学)的研究方法所关注的，这些方法被单独地概括为补充受训者的核心学科重点，但建立在基因组科学的成就和知识的基础上。鉴于威斯康星大学令人难以置信的丰富的科学和工程知识，GSTP能够招募到非常先进的质谱学、微阵列技术、计算和生物设备的优秀实习生，同时探索利用这些优势进行蛋白质组学、转录、代谢组学和基因组生物学的尖端研究的新应用。这一成就催生了我们校园中一个重要的基因组学社区的建立，通过将学员和培训人员联网，成为跨部门、中心和其他培训项目的突破性合作的中心枢纽。我们建议在更新这一计划时，我们继续把重点放在GSTP的程序性评估上，增加分析和解释大数据集的方法开发方面的培训，并促进临床应用。我们要求每年为培训提供资金：10名博士后(1-3年)、4名博士后(1-3年)和2名短期(0.25年期)实习生；我们将寻找具有最近本科生和研究生学位的实习生。

DESCRIPTION (provided by applicant): The Genomic Sciences Training Program (GSTP) is training the new generation of genomic scientists with strengths spanning across multiple disciplines. The training opportunities and environment we propose will enable our trainees to develop and apply new tools, derived from technological advances that are informed by cutting-edge statistical and computational approaches that functionalize diverse and large datasets. The new genomic approaches to biological and medical investigation demand scientists who are knowledgeable and skilled across several fields in effective ways that potentate new insights or inventions. Accordingly, the emergence of new tools allowing for the creation and interpretation of large-scale experimental efforts is what GSTP has focused on by the didactical interweaving of investigative approaches drawn from multiple fields (biology, genetics, physical sciences, engineering, computer science, and statistics) that were individually contoured for complementing a trainee's core disciplinary focus, yet built upon achievement and knowledge within the genomic sciences. Given the incredibly rich scientific and engineering breadth of the University of Wisconsin, GSTP was able to recruit outstanding trainees who greatly advanced mass spectroscopy, microarray technologies, computation, and bio-devices, while exploring new applications leveraging these advantages for cutting-edge investigation into proteomics, transcription, metabolomics, and genome biology. Such achievement has spawned the establishment of a significant genomics community on our campus through networking of trainees and trainers to become central hubs for groundbreaking collaborations reaching across departments, centers, and other training programs. We propose for the renewal of this program that we continue this focus with added emphasis on programmatic evaluation of GSTP, increased training in developing methods for analyzing and interpreting large datasets, and fostering of clinical applications. We request funding for training on a yearly basis: 10 predoctoral (1-3 yrs), 4 postdoctoral (1-3 yrs), and 2 short-term (0.25 yr) trainees; we will seek trainees with recent undergraduate and graduate degrees.