Institutional Training in the Genomic Sciences

描述（由申请人提供）：基因组科学培训计划（GSTP）正在培养跨多个学科的新一代基因组科学家。我们提出的培训机会和环境将使我们的学员能够开发和应用新的工具，这些工具来源于技术进步，这些技术进步是由尖端的统计和计算方法提供的，这些方法可以使多样化和大型数据集发挥功能。生物和医学研究的新基因组方法需要在多个领域具有知识和技能的科学家以有效的方式提供新的见解或发明。因此，新工具的出现允许大规模实验成果的创建和解释是GSTP所关注的，通过从多个领域（生物学，遗传学，物理科学，工程学，计算机科学和统计学）提取的调查方法的教学交织，这些方法被单独轮廓，以补充学员的核心学科重点，但建立在基因组科学的成就和知识基础上。鉴于威斯康星大学丰富的科学和工程广度，GSTP能够招募优秀的学员，他们在质谱，微阵列技术，计算和生物设备方面有很大的进步，同时利用这些优势探索新的应用，进行蛋白质组学，转录，代谢组学和基因组生物学的前沿研究。这样的成就催生了一个重要的基因组学社区的建立，通过学员和培训师的网络，成为跨部门、中心和其他培训项目突破性合作的中心枢纽。我们建议更新该项目，我们将继续关注GSTP的程序性评估，增加开发分析和解释大型数据集的方法的培训，并促进临床应用。我们要求每年提供培训资金：10名博士预科（1-3年），4名博士后（1-3年），2名短期（0.25年）实习生；我们将寻找具有近期本科和研究生学位的学员。

DESCRIPTION (provided by applicant): The Genomic Sciences Training Program (GSTP) is training the new generation of genomic scientists with strengths spanning across multiple disciplines. The training opportunities and environment we propose will enable our trainees to develop and apply new tools, derived from technological advances that are informed by cutting-edge statistical and computational approaches that functionalize diverse and large datasets. The new genomic approaches to biological and medical investigation demand scientists who are knowledgeable and skilled across several fields in effective ways that potentate new insights or inventions. Accordingly, the emergence of new tools allowing for the creation and interpretation of large-scale experimental efforts is what GSTP has focused on by the didactical interweaving of investigative approaches drawn from multiple fields (biology, genetics, physical sciences, engineering, computer science, and statistics) that were individually contoured for complementing a trainee's core disciplinary focus, yet built upon achievement and knowledge within the genomic sciences. Given the incredibly rich scientific and engineering breadth of the University of Wisconsin, GSTP was able to recruit outstanding trainees who greatly advanced mass spectroscopy, microarray technologies, computation, and bio-devices, while exploring new applications leveraging these advantages for cutting-edge investigation into proteomics, transcription, metabolomics, and genome biology. Such achievement has spawned the establishment of a significant genomics community on our campus through networking of trainees and trainers to become central hubs for groundbreaking collaborations reaching across departments, centers, and other training programs. We propose for the renewal of this program that we continue this focus with added emphasis on programmatic evaluation of GSTP, increased training in developing methods for analyzing and interpreting large datasets, and fostering of clinical applications. We request funding for training on a yearly basis: 10 predoctoral (1-3 yrs), 4 postdoctoral (1-3 yrs), and 2 short-term (0.25 yr) trainees; we will seek trainees with recent undergraduate and graduate degrees.