Emotion, communication, & EEG: Development & risk

该项目将使用早期情绪功能和沟通的发展模式来预测生命第二年和第三年的社会，行为和认知功能。100个典型发育的婴儿兄弟姐妹和100个自闭症谱系障碍（ASD）儿童的婴儿兄弟姐妹之间的对比-他们有一系列情感，沟通和认知中断的风险-将从发展心理病理学的角度阐明这些发展过程。在生命的第一年，气质（实验室-TAB）和沟通（面对面/静止的脸）的积极和消极的情绪，接近动机的大脑指数（脑电图偏侧）之间的关联评估，和发展的沟通意向性（婴儿联合注意）将被确定。这些结构将用于预测一组发育相关过程，包括二元关系质量、父母评定的行为困难和优势、语言和认知功能的标准化测量以及生命第二年和第三年的ASD相关行为学。关系质量是一个核心结构，包括安全的依恋，父母的温暖和控制，以及儿童的合作和温暖的一系列社会情况。关系质量预计将介导的途径，所有的结果，除了房间隔缺损诊断。高水平ASD患者的早期情感沟通和后期社交、沟通和认知功能均存在缺陷。ASD的发病与早期情绪功能直接相关。该建议利用多种方法评估婴儿早期的情绪功能，以应对预测有意沟通和健康互动的后期指标以及胜任的语言和认知功能的任务。测试的模型将揭示特定的光预测和预防健康相关的结果，包括行为问题，关系质量差，和ASD的发病率在一个风险和典型的发展样本。在典型发育中的婴儿和ASD儿童的婴儿兄弟姐妹中检查预测关联将揭示健康发育的途径，这些途径的精神病理学偏离，以及有发育困难风险的婴儿的潜在干预策略。

DESCRIPTION (provided by applicant): This project will use developmental patterns of early emotional functioning and communication to predict social, behavioral, and cognitive functioning in the second and third year of life. Contrasts between 100 typically developing infant siblings and 100 infant siblings of children with Autism Spectrum Disorder (ASD) - who are at risk for a range of disruptions of emotion, communication, and cognition - will illuminate these developmental processes from a developmental psychopathology perspective. In the first year of life, associations between temperamental (Lab-TAB) and communicative (face-to-face/still-face) assessments of positive and negative emotion, cerebral indices of approach motivation (EEG laterality), and the development of communicative intentionality (infant joint attention) will be determined. These constructs will be used to predict a set of developmental^ linked processes including dyadic relationship quality, parent rated behavioral difficulties and strengths, standardized measures of linguistic and cognitive functioning, and ASD- related symptomatology in the second and third year of life. Relationship quality is a central construct, encompassing security of attachment, parental warmth and control, and child cooperation and warmeth in a range of social situations. Relationship quality is expected to mediate pathways to all outcomes with the exception of ASD symptomatology. Children with high levels of ASD symptomatology are expected to show deficits in both early measures emotional communication and later measures of social, communicative, and cognitive functioning. ASD symptomatology is expected to be directly related to early emotional functioning. This proposal utilizes multi-method assessment of emotional functioning early in infancy to confront the task of predicting intentional communication and later indices of healthy interaction, and competent linguistic and cognitive functioning. The models tested will shed specific light on the prediction and prevention of health- related outcomes including behavior problems, poor relationship quality, and ASD symptomatology in an at- risk and typically developing sample. Examination of predictive associations in typically developing infants and infant siblings of children with ASD will shed light on pathways to healthy development, psychopathologic deviations from those pathways, and potential intervention strategies for infants at risk for developmental difficulties.