Biobehavioral Effects of Qigong During Treatment for Rectal Cancer

气功治疗直肠癌的生物行为效应

• 批准号: 7591776
• 负责人: Lorenzo Cohen
• 金额: $ 21.89万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591776
• 关键词: Acute; Adjuvant; Adverse effects; Aftercare; Anxiety; Attention; Breathing; Buffers; Cancer Patient; Cessation of life; Client satisfaction; Cognitive; Combined Modality Therapy; Control Groups; Desire for food; Diagnosis; Disease Progression; Distress; Dose; Educational process of instructing; Emotional; Evaluation; Exercise; Fatigue; Frequencies; Fright; Health; Hospitals; Intestines; Light Exercise; Malignant Neoplasms; Measures; Mediator of activation protein; Meditation; Mental Health; Morbidity - disease rate; Movement; Operative Surgical Procedures; Participant; Patients; Physical Function; Physiological; Pilot Projects; Population; Postoperative Period; Process; Psyche structure; Psychological Side Effects; Qi; Qi Gong; Quality of life; Questionnaires; Radiation; Radiation therapy; Radiation-Sensitizing Agents; Randomized; Recovery; Rectal Cancer; Recurrence; Relaxation Techniques; Reporting; Research; Schedule; Sexual Dysfunction; Skin; Sleep disturbances; Social Functioning; Social support; Source; Spirituality; Staging; Stress; Stretching; Structure; Techniques; Testing; Time; Treatment Protocols; Treatment-Related Cancer; Visit; biobehavior; cancer therapy; chemotherapy; coping; depression; experience; follow up assessment; improved; indexing; interest; programs; psychologic; public health relevance; social; stress management; stressor; treatment effect; treatment planning; visual imagery

DESCRIPTION (provided by applicant): Cancer and its treatment are associated with considerable distress, impaired quality of life, poor mental health, and reduced physical function. This is particularly true for patients with rectal cancer who receive multimodal treatment over an extended period of time. Most patients will undergo radiotherapy, followed by surgery and often chemotherapy. It is important to develop programs that can help ameliorate the treatment-related morbidity that accumulates over time for patients with rectal cancer. Furthermore, given the stressful time demands of undergoing radiotherapy (patients typically receive treatment 5 days per week for 6 weeks) it is crucial that programs be easily incorporated into the treatment schedule. Research suggests that stress- reduction programs tailored to the cancer setting help patients cope with the acute effects of treatment and improve QOL after treatment. Qigong, an ancient practice for manipulating one's own Qi (energy flow) to benefit one's physical, emotional, mental, or spiritual health incorporates stress-reduction techniques including regulated breathing, visual imagery, meditation, and various gentle movements. Qigong may be particularly useful for patients with rectal cancer while undergoing radiation treatment and prior to surgery and chemotherapy because of the stress management and relaxation techniques and the gentle movements that should facilitate recovery. In this feasibility/pilot project, we will pilot-test and examine the feasibility and usefulness of conducting a Qigong program with rectal cancer patients as an adjuvant to their radiotherapy treatment. Rectal cancer patients undergoing radiotherapy treatment will be randomly assigned Patients with rectal cancer who are undergoing chemo-radiotherapy will be randomly assigned to either a Qigong group (QI), or a light exercise control group (LE), or a waitlist control group (WL). Participants in the QI and LE groups will attend sessions 3 days/week throughout their 6-week radiotherapy schedule. The sessions will be coordinated with the treatment schedule and conducted adjacent to the treatment facility. Measures will be obtained prior to randomization, a brief assessment in the middle of radiotherapy, during last week of radiotherapy, and 1 and 3 months after the end of radiotherapy. In addition to determining the acceptability and feasibility of the program, this study will also examine the effects of the Qigong program on fatigue and sleep disturbances. Secondary indices of adjustment include QOL and mental health. We hypothesize that the Qigong program will be feasible and that patients will find the program acceptable and a positive experience. Integrating a Qigong program into the treatment regimen for patients undergoing radiotherapy will make it relatively easy to participate in the program and we hypothesize that such a program will help facilitate recovery and alleviate the psychological and physiological side effects experienced by patients who are currently undergoing radiotherapy. Public Health Relevance Paragraph: The proposed study will examine the feasibility and initial usefulness of incorporating a Qigong program alongside radiotherapy for patients with rectal cancer. If we find that the Qigong program facilitates recovery and alleviates the psychological and physiological side effects experienced by patients undergoing radiotherapy then this type of program can be incorporated into the treatment plan. As the proposed trial is a feasibility/pilot project a larger trial would need to be conducted and possibly include other cancer populations undergoing radiotherapy.

描述（由申请人提供）：癌症及其治疗与相当大的痛苦、生活质量受损、心理健康状况不佳和身体机能下降有关。对于长期接受多模式治疗的直肠癌患者尤其如此。大多数患者将接受放疗，然后进行手术，通常还进行化疗。制定有助于改善直肠癌患者随时间累积的治疗相关发病率的计划非常重要。此外，考虑到接受放射治疗的紧张时间要求（患者通常每周接受治疗 5 天，持续 6 周），将计划轻松纳入治疗计划至关重要。研究表明，针对癌症情况量身定制的减压计划可以帮助患者应对治疗的急性影响并改善治疗后的生活质量。气功是一种操纵自身气（能量流）以有益于身体、情感、心理或精神健康的古老​​练习，它结合了减压技术，包括调节呼吸、视觉意象、冥想和各种轻柔的动作。气功对于直肠癌患者在接受放射治疗期间以及手术和化疗之前可能特别有用，因为气功可以进行压力管理和放松技巧以及有助于康复的温和运动。在这个可行性/试点项目中，我们将试点并研究对直肠癌患者进行气功计划作为放射治疗辅助的可行性和有用性。接受放疗的直肠癌患者将被随机分配接受放化疗的直肠癌患者将被随机分配到气功组（QI）、轻度运动对照组（LE）或候补对照组（WL）。 QI 和 LE 组的参与者将在为期 6 周的放射治疗计划中每周参加 3 天的会议。这些疗程将与治疗计划相协调，并在治疗设施附近进行。将在随机分组之前、在放疗中间、放疗最后一周以及放疗结束后 1 个月和 3 个月内进行简短评估。除了确定该计划的可接受性和可行性外，本研究还将研究气功计划对疲劳和睡眠障碍的影响。次要调整指标包括生活质量和心理健康。我们假设气功项目是可行的，并且患者会发现该项目是可接受的并且是一种积极的体验。将气功项目纳入放疗患者的治疗方案将使参与该项目相对容易，我们假设这样的项目将有助于促进康复并减轻目前正在接受放疗的患者所经历的心理和生理副作用。 公共卫生相关段落：拟议的研究将探讨将气功项目与放疗结合用于直肠癌患者的可行性和初步有效性。如果我们发现气功项目有助于康复并减轻接受放射治疗的患者所经历的心理和生理副作用，那么此类项目可以纳入治疗计划中。由于拟议的试验是一个可行性/试点项目，因此需要进行更大规模的试验，并可能包括接受放射治疗的其他癌症人群。