Bioinformatics/Biostatistical Core

支持5-羟色胺的信号网络的范德比尔特康特神经科学研究中心 运输涉及多个调查人员和核心资源，以检查和定义遗传，分子， 支持5 HT神经元身份、发育、信号传导和可塑性的生物化学和细胞网络。 从这些基础研究的进展最终到更多的生物医学研究的转化领域。 生物信息学/生物统计学核心在生物信息学和生物统计学方面的进展还应 对生物医学研究和开发的其他领域产生影响。生物信息学与生物统计学 核心将合并生物统计学系和生物医学系的几名教职员工的努力 范德比尔特大学医学中心的信息学系支持孔蒂中心。一个关键 功能将是实验的统计设计和生物信息学设计的数据结构和元数据， 有助于确保有效地收集和分析最有意义的实验数据。芯会 使用生物统计学和生物信息学诊所，并继续这些诊所的工作。这些诊所将允许 实验学家提出更广泛的讨论“案例”的研究问题和实验。这些 诊所还将允许生物统计学和生物信息学专家安排相关主题的简短教程， 这些情况和工具的使用。因此，这些诊所应促进深入和持续的跨学科 实验前、实验产生数据后和初始数据后的交互 分析.将在数据的统计和生物信息学分析方面提供指导和专门支持 使用我们开发的工具或方法以及其他人的工具或方法。我们 将开发一个门户网站SerotoninWorld.net，该网站将发挥若干关键作用。它将促进内部 研究人员之间的合作和分享初步数据和分析。它将促进共享 完整的资源，以整个研究5 HT和神经科学研究界。该门户网站将 还提供了教育和更广泛的外联机会。这个入口将帮助 我们将继续努力， 出版物和资源。将创建若干数据分析工具和方法，包括 WebGestalt的进一步发展和客户端版本应该直接影响5 HT研究 社区本项目开发的可通过网络访问的数据分析工具将提供给所有 研究社区。我们将开发和利用几个开源项目，并将它们托管在 sourceforge.net以供更广泛的社区使用和开发。

The Vanderbilt Conte Center for Neuroscience Research Signaling Networks Supporting Serotonin Transport engages multiple investigators and core resources to examine and define genetic, molecular, biochemical and cellular networks supporting of 5HT neuronal identity, development, signaling and plasticity. Advances from these basic studies ultimately to more translational arenas of biomedical research. Advances in bioinformatics and biostatistics created by the Bioinformatics/Biostatistics Core should also have impact in other areas of biomedical research and development. The Bioinformatics and Biostatistics Core will merge the efforts of several faculty and staff of the Biostatistics Department and the Biomedical Informatics Department at Vanderbilt University Medical Center in support of the Conte center. A key function will be statistical design of experiments and bioinformatics design of data structure and metadata to help ensure that the most meaningful experimental data is efficiently collected and analyzed. The core will use Biostatistics and Bioinformatics clinics and follow on work from these clinics. These clinics will allow experimentalists to produce for broader discussion "cases" of research problems and experiments. These clinics will also allow biostatistics and bioinformatics experts to arrange short tutorials in relevant topics for these cases and in the use of tools. Thus, these clinics should foster deep and ongoing interdisciplinary interactions before the experiments are done, after the experiments produce data, and after initial data analysis. Guided and dedicated support will be offered in the statistical and bioinformatics analysis of data sets from this center using the tools or approaches we develop and the tools or approaches of others. We will develop a web portal, SerotoninWorld.net that will perform several key functions. It will foster internal collaboration and sharing of preliminary data and analysis among researchers. It will foster sharing of completed resources to the entire research 5HT and neuroscience research community. This web portal will also provide an opportunity for education and broader outreach. This portal will assist in the greater ¿:suepmpaonrticmoertghaondiszationenoafbdleatainteoresutepdporbtiocmomedpiucatelr-raeseisatrecdhearscceinss5HtoTthresereasrecahrctoh rgestouarcceess.s Wtoenwewill publications and resources. Several tools and approaches to the analysis of data will be created, including the further development of WebGestalt and a client version that should directly affect the 5HT research community. Web-accessible data analysis tools developed in this project will be available to the entire research community. We will develop and exploit several open source projects and host them on sourceforge.net for broader community use and development.