Bioinformatics/Biostatistical Core

范德比尔特神经科学研究中心支持5-羟色胺的信号网络 TRANSPORT聘请了多名研究人员和核心资源来检查和定义遗传、分子 生化和细胞网络支持5-羟色胺神经元的识别、发育、信号和可塑性。 从这些基础研究到生物医学研究的更具翻译性的领域。 生物信息学/生物统计学核心创建的生物信息学和生物统计学的进展也应该 对生物医学研究和开发的其他领域产生影响。生物信息学与生物统计学 CORE将合并生物统计系和生物医学系的几名教职员工的努力 范德比尔特大学医学中心信息学系支持孔特中心。一把钥匙 功能将统计设计的实验和生物信息学设计的数据结构和元数据 帮助确保高效地收集和分析最有意义的实验数据。核心将会 使用生物统计学和生物信息学诊所，并跟进这些诊所的工作。这些诊所将允许 实验者产生研究问题和实验的“案例”以供更广泛的讨论。这些 诊所还将允许生物统计学和生物信息学专家在相关主题中安排简短的教程 在这些情况下，在使用工具方面。因此，这些诊所应该培养深入和持续的跨学科 在实验完成之前、实验产生数据之后和初始数据之后的交互 分析。将在数据的统计和生物信息学分析方面提供指导和专门的支助 使用我们开发的工具或方法以及其他人的工具或方法从这个中心设置。我们 将开发一个门户网站SerotoninWorld.net，它将执行几个关键功能。它将促进内部 研究人员之间的初步数据和分析的协作和共享。它将促进共享 向整个研究5HT和神经科学研究社区提供完整的资源。这个门户网站将 也为教育和更广泛的外展提供了机会。此门户将帮助更大的 ¿：suepmpaonrticmoertghaondiszationenoafbdleatainteoresutepdporbtiocmomedpiucatelr-raeseisatrecdhearscceinss5HtoTthresereasrecahrctoh rsterouarcces.s Wtoenwewill 出版物和资源。将创建几种分析数据的工具和方法，包括 WebGestalt的进一步发展和客户端版本应该会直接影响5HT的研究 社区。在本项目中开发的可通过Web访问的数据分析工具将向整个 研究社区。我们将开发和利用几个开源项目，并将它们托管在 SourceForge.net，用于更广泛的社区使用和开发。

The Vanderbilt Conte Center for Neuroscience Research Signaling Networks Supporting Serotonin Transport engages multiple investigators and core resources to examine and define genetic, molecular, biochemical and cellular networks supporting of 5HT neuronal identity, development, signaling and plasticity. Advances from these basic studies ultimately to more translational arenas of biomedical research. Advances in bioinformatics and biostatistics created by the Bioinformatics/Biostatistics Core should also have impact in other areas of biomedical research and development. The Bioinformatics and Biostatistics Core will merge the efforts of several faculty and staff of the Biostatistics Department and the Biomedical Informatics Department at Vanderbilt University Medical Center in support of the Conte center. A key function will be statistical design of experiments and bioinformatics design of data structure and metadata to help ensure that the most meaningful experimental data is efficiently collected and analyzed. The core will use Biostatistics and Bioinformatics clinics and follow on work from these clinics. These clinics will allow experimentalists to produce for broader discussion "cases" of research problems and experiments. These clinics will also allow biostatistics and bioinformatics experts to arrange short tutorials in relevant topics for these cases and in the use of tools. Thus, these clinics should foster deep and ongoing interdisciplinary interactions before the experiments are done, after the experiments produce data, and after initial data analysis. Guided and dedicated support will be offered in the statistical and bioinformatics analysis of data sets from this center using the tools or approaches we develop and the tools or approaches of others. We will develop a web portal, SerotoninWorld.net that will perform several key functions. It will foster internal collaboration and sharing of preliminary data and analysis among researchers. It will foster sharing of completed resources to the entire research 5HT and neuroscience research community. This web portal will also provide an opportunity for education and broader outreach. This portal will assist in the greater ¿:suepmpaonrticmoertghaondiszationenoafbdleatainteoresutepdporbtiocmomedpiucatelr-raeseisatrecdhearscceinss5HtoTthresereasrecahrctoh rgestouarcceess.s Wtoenwewill publications and resources. Several tools and approaches to the analysis of data will be created, including the further development of WebGestalt and a client version that should directly affect the 5HT research community. Web-accessible data analysis tools developed in this project will be available to the entire research community. We will develop and exploit several open source projects and host them on sourceforge.net for broader community use and development.