MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY

自身免疫性视网膜病视网膜损伤的机制

• 批准号: 7715961
• 负责人: Brett G Jeffrey
• 金额: $ 2.77万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715961
• 关键词: Antibodies; Autoantibodies; Autoimmune Process; Blindness; Body part; Computer Retrieval of Information on Scientific Projects Database; Cornea; Disease; Distal; Electrodes; Electroretinography; Functional disorder; Funding; Grant; Immune response; Injection of therapeutic agent; Institution; Lead; Light; Malignant Neoplasms; Molecular; Patients; Prevention; Proteins; Rattus; Research; Research Personnel; Resources; Retina; Retinal; Retinal Degeneration; Retinal Diseases; Serum; Source; Testing; United States National Institutes of Health; response; retinal damage; voltage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cancer Associated Retinopathy (CAR) is a paraneoplastic disease in which retinal degeneration occurs as a result of the patient's immune response to cancer in a distal part of the body. Treatment for the primary malignancy does not alter the course of visual loss and there is neither a means of cure nor prevention of such retinal degenerations. Autoantibodies against retinal proteins are present in serum of CAR patients but whether these antibodies themselves induce retinal degeneration is a source of debate. Retinal dysfunction or degeneration is assessed by recording the electroretinogram (ERG). The ERG is a recording of the change in voltage across the retina in response to light and is recorded from an electrode placed against the cornea. The aim of the proposed studies was to use the ERG to assess changes in retinal function in rats following intravitreal injection autoantibodies isolated from CAR patients. The overall aim of the research is to determine the molecular mechanisms altered by autoantibodies against retinal proteins that lead to retinal degeneration. Understanding the molecular mechanisms that result in retinal degeneration in these patients is the first step towards the developing and testing of preventative treatments.

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