Research Administration Core, Human DNA Samples Bank, Animal Models, & Databases

研究管理核心、人类 DNA 样本库、动物模型、

• 批准号: 7661410
• 负责人: Emmanuel J Mignot
• 金额: $ 30.49万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7661410
• 关键词: Adherence; Administrator; Affect; American; Animal Genetics; Animal Model; Animals; Antigen-Presenting Cells; Appendix; Award; Biological; Brain; Canis familiaris; Cataplexy; Cerebrospinal Fluid; Clinic; Communication; Complex; Critiques; DNA; DNA Library; Data; Databases; Diagnosis; Diagnostic Procedure; Discipline; Disease; Dissection; Documentation; Ensure; Faculty; Functional disorder; Funding; Genes; Genetic; Goals; Grant; Guidelines; HLA Antigens; Histamine; Human; Human Genetics; Lead; Leadership; Left; Maintenance; Modeling; Mus; Narcolepsy; Operative Surgical Procedures; Patients; Physiology; Policies; Prevalence; Principal Investigator; Program Research Project Grants; Psychiatry; Publications; Rattus; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Research Training; Resources; Rodent; Running; Sampling; Schools; Scientist; Seasons; Serum; Sleep; Specimen; Support of Research; Susceptibility Gene; Therapeutic; Tissue Sample; Title; United States National Institutes of Health; Universities; Wisconsin; Work; Zebrafish; animal colony; base; computerized; day; hypocretin; improved; member; multidisciplinary; nervous system disorder; neurochemistry; neuropathology; neurotransmission; novel; novel diagnostics; programs; translational approach

DESCRIPTION (provided by applicant): During the last 18 years of funding of this program project, the only NIH supported program project focused on narcolepsy, we have made significant strides in understanding the pathophysiology of narcolepsy, as well as the physiology of normal sleep. Our discovery during the last funding period that most cases of human narcolepsy cataplexy are caused by hypocretin (also called orexin) deficiency significantly changed the sleep field. In this revised competitive renewal proposal, based on our recent discoveries, we have refocused our research efforts and recruited new members to expand the expertise of the Center. In this revised proposal, we have brought together a unique group of independent investigators working across disciplines toward a common goal. Based on the reviewers' critiques, we have removed two projects from our original proposal, leaving four projects and a core (Project A). The core (Project A) provides the necessary core resources to support research projects at the Stanford Center for Narcolepsy, most notably biological samples. The goal of Project B, directed by Dr. Terry Young at the University of Wisconsin, Madison is to determine the prevalence of narcolepsy without cataplexy using an epidemiological approach and to study its association with HLA and lypocretin deficiency. Project D, directed by Dr. Juliette Faraco, will use a zebrafish model to isolate novel genes regulating hypocretin and histamine neurotransmission. In Project F, directed by Dr. Luis de Lecea, the discoverer of hypocretins, is seeking to identify novel genes with preferential expression in hypocretin-containing cells; an accessory goal of this project will be to study the neuropathology of narcolepsy without cataplexy. Project E, directed by Dr. Joachim Hallmayer, will use a human genetic approach to identify novel narcolepsy susceptibility genes. Narcolepsy is a frequent and disabling neurological disorder affecting more than 1 in 2,000 Americans. Our recent findings have led to new diagnostic procedures but have not yet changed therapeutic options. Our aims are improved diagnosis, a better understanding of the narcolepsy pathophysiology and the discovery of new treatments, if not a cure for narcoleptic patients. PROJECT A PI: Emmanuel Mignot Title: Research Administration Core, Human DNA Samples Bank, Animal Models, & Databases Description (provided by applicant): A seasoned and well-trained research administration staff is essential for the effective management of a complex multi-disciplinary program project. During the last consecutive 18 years of funding of this program project the Principal Investigator and the Assistant Director of the Sleep Research Center have worked together and built a team of research administrators and research support staff that are responsible for the day-to-day activities of managing the Center for Narcolepsy. This includes budgetary and fiscal reporting planning, oversight of policy and guidelines, animal and human database management, subject recruitment and the integration of this project into the Sleep Research Center and Sleep Clinic, and in general ensuring that the program runs smoothly. To support this revised research proposal, five main core activities are recognized: 1) A research administrative and coordinating function to facilitate the research & interactions among investigators and projects 2) Management of the Stanford University Center for Narcolepsy animal colonies used in this proposal; this includes zebrafish, mice, and rats. 3) Recruitment of human narcolepsy patients for research projects: this includes the banking of DNA, serum, cerebrospinal fluid and brain specimens from narcolepsy and control subjects. 4) Maintenance of computerized databases containing human, mouse/rat, canine narcolepsy data and tissue sample data; maintenance of the project's website and data-sharing on-line. 5) Maintenance of all documentation supporting adherence to all federal guidelines and policies for conducting research. It is the responsibility of the Principal Investigator to assure that the Center for Narcolepsy scientists work as an integrated team. His direction and scientific leadership, is essential to the pursuit of the overall goals of the program. A weekly research meeting is held to facilitate communication among the investigators and between the research staff and research administration staff.

描述（由申请人提供）：在过去18年的资助这个计划项目，唯一的NIH支持的计划项目集中在嗜睡症，我们已经取得了重大进展，了解嗜睡症的病理生理学，以及正常睡眠的生理学。我们在上一个资助期间发现，大多数人类发作性睡病的病例是由下丘脑泌素（也称为食欲素）缺乏引起的，这一发现显著改变了睡眠领域。在这个修订后的竞争性更新提案中，根据我们最近的发现，我们重新调整了我们的研究工作，并招募了新成员，以扩大中心的专业知识。在这份修订后的提案中，我们召集了一组独特的独立调查人员，他们跨学科工作，朝着一个共同的目标努力。根据审查人员的批评，我们从最初的提案中删除了两个项目，留下四个项目和一个核心项目（项目A）。核心（项目A）提供必要的核心资源，以支持斯坦福大学嗜睡症中心的研究项目，最主要的是生物样本。麦迪逊的威斯康星州大学的Terry Young博士指导的项目B的目标是使用流行病学方法确定无cataepsy发作性睡病的患病率，并研究其与HLA和脂泌素缺乏症的关系。由Juliette Faraco博士指导的D项目将使用斑马鱼模型分离调节下丘脑泌素和组胺神经传递的新基因。在项目F中，由下丘脑泌素的发现者Luis de Lecea博士指导，正在寻找在含下丘脑泌素的细胞中优先表达的新基因;该项目的辅助目标将是研究无cataerosis的发作性睡病的神经病理学。由Joachim Hallmayer博士指导的项目E将使用人类遗传学方法来识别新的嗜睡症易感基因。嗜睡症是一种常见的致残性神经系统疾病，影响超过1/2000的美国人。我们最近的发现导致了新的诊断程序，但尚未改变治疗选择。我们的目标是改善诊断，更好地了解发作性睡病的病理生理学和发现新的治疗方法，如果不能治愈发作性睡病患者。 项目A 主要研究者： 伊曼纽尔·米尼奥 职务名称： 研究管理核心，人类DNA样本库，动物模型和数据库 描述（由申请人提供）：一个经验丰富，训练有素的研究管理人员是一个复杂的多学科计划项目的有效管理至关重要。在过去连续18年的资助该计划项目的主要研究者和睡眠研究中心的助理主任一起工作，并建立了一个研究管理员和研究支持人员团队，负责管理嗜睡症中心的日常活动。这包括预算和财务报告规划，监督政策和指导方针，动物和人类数据库管理，受试者招募以及将该项目整合到睡眠研究中心和睡眠诊所，并确保该项目顺利运行。为了支持这一修订后的研究提案，确认了五项主要核心活动：1）研究管理和协调职能，以促进研究者和项目之间的研究和互动2）管理本提案中使用的斯坦福大学嗜睡症动物群中心;这包括斑马鱼、小鼠和大鼠。3)为研究项目招募人类嗜睡症患者：这包括来自嗜睡症和对照受试者的DNA、血清、脑脊液和脑标本的库。4)维护计算机化数据库，其中包括人类、小鼠/大鼠、犬嗜睡症数据和组织样本数据;维护项目网站和在线数据共享。5)维护所有支持遵守所有联邦指导方针和政策进行研究的文件。主要研究者有责任确保嗜睡症中心的科学家作为一个综合团队开展工作。他的方向和科学的领导，是必不可少的追求的总体目标的计划。每周举行一次研究会议，以促进研究者之间以及研究人员和研究管理人员之间的沟通。