J.P.Kennedy Mental Retardation and Developmental Disabilities Center

描述（由申请人提供）：芝加哥大学智力发育迟缓和发育障碍研究中心（MRDDRC）位于约瑟夫·p·肯尼迪智力发育迟缓研究中心。MRDDRC已被指定为一个全校范围的研究所，扩大了芝加哥大学科学家的社区，他们致力于大脑和行为发展研究，以及诊断和治疗导致智力迟钝和残疾的个体。为此，MRDDRC包括来自芝加哥大学和其他芝加哥机构的47名研究人员，他们已经获得了80多个项目的联邦支持。该MRDDRC的目标是通过结合生物医学和行为科学的一系列研究方法，推进智力迟钝和发育障碍的诊断、预防、治疗和改善。该申请人的具体目标是1)扩大MRDD的研究基础，2)促进多学科方法并加强合作，3)通过提供具有成本效益的创新核心设施来提高中心研究人员的生产力，4)促进MRDD研究的教育，培训和交流，5)促进互动和分享专业知识。芝加哥大学以外的研究者已经对MRDD做出了强有力的承诺。这些目标将由行政核心和三个科学核心：基因组学和生物信息学核心，模式生物核心和神经科学核心来促进。jp Kennedy MRDDRC的研究范围非常广泛，包括大脑发育的遗传、生化、细胞、生理和行为研究，以及特定发育障碍的转化和临床研究，包括癫痫、自闭症、小脑畸形、神经桶缺陷、攻击/爆炸障碍、药物成瘾、精神分裂症、双相情感障碍、多动症、神经变性疾病和巴顿病。本中心申请的总体目标是通过核心设施基础设施和跨机构互动，促进芝加哥地区智力迟钝和发育障碍研究的质量、深度和转化相关性。

DESCRIPTION (provided by applicant): The University of Chicago Mental Retardation and Developmental Disabilities Research Center (MRDDRC) is based in the Joseph P. Kennedy Mental Retardation Research Center. The MRDDRC has been designated a University-wide institute, expanding the community of University of Chicago scientists who are committed to brain and behavioral development research and the diagnosis and treatment of individuals with afflictions leading to mental retardation and disabilities. To this end the MRDDRC includes 47 researchers from the University of Chicago and other Chicago institutions who have received federal support for over 80 projects. The objective of this MRDDRC is to advance the diagnosis, prevention, treatment and amelioration of mental retardation and developmental disabilities by incorporating a range of research approaches from the biomedical and behavioral sciences. The specific objectives of this applicant are to 1) expand the research base in MRDD, 2) promote a multidisciplinary approach and enhance collaboration, 3) increase the productivity of Center investigators by providing cost effective, innovative core facilities, 4) foster education, training and communication in MRDD research, and 5) promote interaction and share expertise, approaches and patients with investigators outside the University of Chicago who have demonstrated a strong commitment to MRDD. These objectives will be fostered by the Administrative Core, and three scientific cores: Genomics and Bioinformatics Core, Model Organisms Core and Neuroscience Core. The scope of the J.P. Kennedy MRDDRC research portfolio is remarkably broad, encompassing genetic, biochemical, cellular, physiological and behavioral studies of brain development as well as translational and clinical research on specific developmental disabilities including epilepsy, autism, cerebellar malformations, neural tub defects, aggression/explosive disorder, drug addiction, schizophrenia, bipolar disorder, ADHD, neurogenerative diseases, and Batten's disease. The overarching goal of this Center application is to promote, through core facility infrastructure and trans-institutional interactions, the quality, depth and translational relevance of Chicago-area research into mental retardation and developmental disabilities.