Core--Pathology/Morphology/Imaging Facility

描述(由申请人提供)：病理/形态/影像设施提供 组织学、免疫化学、原位杂交、共聚焦、激光解剖和形态计量学研究方面的设备和技术专长。在上一个供资期间，其服务有了重大改进，包括荧光显微镜、免疫染色、激光捕获显微解剖和其他技术。该设施分为病理/形态学主实验室、软组织原位杂交分子形态实验室、免疫染色实验室、硬组织组织学、形态计量学和硬组织原位杂交实验室。共焦成像由大学设施核心实验室提供。每个实验室都由一名位于实验室附近的中心赠款成员监督，每个成员都广泛使用他们监督下的实验室技术。核心由巴格斯博士指导，他是系统中所有潜在用户的初始联系人，该系统旨在增强该设施的易用性。费用是根据与EHSC或罗切斯特大学的联系来征收的。提供了中心奖助金成员使用的大量文件。该设施性质的一个重大变化是免疫染色实验室与病理部门的合作，这将允许更有效地使用仪器和试剂，并通过租赁/维护协议保证使用最新的设备。

Description (provided by applicant): The Pathology/Morphology/Imaging Facility provides the equipment and technical expertise in conducting studies involving histology, immunochemistry, in situ hybridization, confocal, laser dissection and morphometrics. Significant enhancements in its services have occurred over the previous funding period, including fluorescence microscopy, immunostaining, laser capture microdissection and other techniques. The facility is divided into a main lab for pathology/morphology, a molecular morphology lab for in situ hybridization of soft tissues, an immunostaining lab, and a hard tissue histology, morphometry and in situ hybridization of hard tissues. Confocal imaging is provided through a University Facilities Core lab. Each lab is overseen by a Center grant member who is physically located near the lab, and each of whom extensively uses the techniques of the lab under their supervision. The core is directed by Dr. Baggs, who is the initial contact for all potential users in a system designed to enhance the ease of use of this facility. Charges are levied according to affiliation with the EHSC or University of Rochester. Extensive documentation of use by members of the Center grant is provided. A major change in the nature of the facility is the partnering of the immunostaining lab with the Pathology department, which should allow more efficient use of instruments and reagents and guarantee the use of updated equipment through lease/maintenance agreements.