Core--Pathology/Morphology/Imaging Facility

描述（由申请人提供）：病理学/形态学/成像机构提供 在组织学、免疫化学、原位杂交、共聚焦、激光解剖和形态测量学等研究领域拥有丰富的设备和技术专长。在上一个供资期间，其服务得到了显著加强，包括荧光显微镜、免疫染色、激光捕获显微切割和其他技术。该设施分为病理学/形态学主实验室、软组织原位杂交分子形态学实验室、免疫染色实验室和硬组织组织学、形态测定和硬组织原位杂交。共聚焦成像是通过大学设施核心实验室提供的。每个实验室都由一名中心资助成员监督，该成员实际上位于实验室附近，每个人都在他们的监督下广泛使用实验室的技术。核心由巴格斯博士指导，他是旨在提高该设施易用性的系统中所有潜在用户的最初联系人。收费是根据与EHSC或罗切斯特大学的隶属关系征收的。提供了中心赠款成员使用的大量文件。该设施性质的一个重大变化是免疫染色实验室与病理部门结成伙伴关系，这将使仪器和试剂得到更有效的使用，并通过租赁/维护协议保证使用最新设备。

Description (provided by applicant): The Pathology/Morphology/Imaging Facility provides the equipment and technical expertise in conducting studies involving histology, immunochemistry, in situ hybridization, confocal, laser dissection and morphometrics. Significant enhancements in its services have occurred over the previous funding period, including fluorescence microscopy, immunostaining, laser capture microdissection and other techniques. The facility is divided into a main lab for pathology/morphology, a molecular morphology lab for in situ hybridization of soft tissues, an immunostaining lab, and a hard tissue histology, morphometry and in situ hybridization of hard tissues. Confocal imaging is provided through a University Facilities Core lab. Each lab is overseen by a Center grant member who is physically located near the lab, and each of whom extensively uses the techniques of the lab under their supervision. The core is directed by Dr. Baggs, who is the initial contact for all potential users in a system designed to enhance the ease of use of this facility. Charges are levied according to affiliation with the EHSC or University of Rochester. Extensive documentation of use by members of the Center grant is provided. A major change in the nature of the facility is the partnering of the immunostaining lab with the Pathology department, which should allow more efficient use of instruments and reagents and guarantee the use of updated equipment through lease/maintenance agreements.