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Academic Training in Trauma and Burns

创伤和烧伤学术培训

基本信息

批准号：
7649332
负责人：
MARC D. BASSON
金额：
$ 8.61万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
起止时间：
1992-07-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7649332
关键词：
Academic Training Burn Trauma

项目摘要

DESCRIPTION (provided by applicant): Trauma and burns are the leading cause of death and morbidity in young individuals. Despite modest advances in the early care of these patients, complications and mortality associated with hemorrhage, shock, tissue injury, infection, wound healing and multi system organ failure remain excessive. Continued improvements in patient outcomes will require fundamental research to identify novel treatment strategies. The objective of the proposed program is to identify and train young surgeons for continuing, productive academic careers focusing of problems relating to trauma and burns. The program insures that individuals possess the necessary basic science and clinical research skills as well as the environment to successfully both identify and subsequently investigate key research questions that will affect the understanding and management of problems affecting trauma and burn victims. Clinical advances in trauma and burn care require not only careful definition of current problems and deliberate basic investigations of ongoing pathophysiologic questions, but also application of leading edge methodologies in order to provide meaningful answers. The proposed program exposes surgical trainees to state of the art basic science research techniques and strategies to allow future academic success. This proposal involves 3 trainees/year who are general surgery residents and will spend a minimum of two years doing basic research.

描述（由申请人提供）：创伤和烧伤是年轻人死亡和发病的主要原因。尽管这些患者的早期护理取得了一定进展，但与出血、休克、组织损伤、感染、伤口愈合和多系统器官衰竭相关的并发症和死亡率仍然过高。患者治疗效果的持续改善需要基础研究来确定新的治疗策略。拟议计划的目标是识别和培训年轻的外科医生，使其能够继续、富有成效的学术生涯，重点关注与创伤和烧伤相关的问题。该计划确保个人拥有必要的基础科学和临床研究技能以及成功识别和随后调查关键研究问题的环境，这些问题将影响对影响创伤和烧伤受害者的问题的理解和管理。创伤和烧伤护理的临床进展不仅需要仔细定义当前问题并对正在进行的病理生理学问题进行深思熟虑的基础研究，还需要应用前沿方法以提供有意义的答案。拟议的计划让外科学员接触最先进的基础科学研究技术和策略，以实现未来的学术成功。该提案每年涉及 3 名普通外科住院医师实习生，并将花至少两年时间进行基础研究。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A large PEST-like sequence directs the ubiquitination, endocytosis, and vacuolar degradation of the yeast a-factor receptor.

DOI：
10.1083/jcb.142.4.949
发表时间：
1998-08-24
期刊：
The Journal of cell biology
影响因子：
0
作者：
Roth AF;Sullivan DM;Davis NG
通讯作者：
Davis NG

Extracellular pressure stimulates tumor cell adhesion in vitro by paxillin activation.

细胞外压力通过桩蛋白激活在体外刺激肿瘤细胞粘附。

DOI：
10.4161/cbt.5.9.3002
发表时间：
2006
期刊：
Cancer biology & therapy
影响因子：
3.6
作者：
vanZyp,JvanderVoort;Conway,WC;Craig,DH;vanZyp,NvanderVoort;Thamilselvan,V;Basson,MD
通讯作者：
Basson,MD

A surgeon's guide to the universe.

外科医生的宇宙指南。

DOI：
10.1016/j.surg.2005.08.010
发表时间：
2006
期刊：
Surgery.
影响因子：
0
作者：
McFarlin,Kellie;Sargsyan,AshotE;Melton,Shannon;Hamilton,DouglasR;Dulchavsky,ScottA
通讯作者：
Dulchavsky,ScottA

The effects of mechanical forces on intestinal physiology and pathology.