Molecular basis and inhibition of TIR-domain function in Toll-like receptor and neuronal cell-death pathways

点击翻译按钮获取中文摘要

A protein domain called TIR domain plays key roles in signalling in innate immunity pathways, associated with chronic inflammatory diseases, and the axon degeneration pathway, a pathway central to neurodegenerative disorders. We found that TIR domains form large assemblies and at least in some cases possess enzymatic activity. Through characterizing the molecular details of these functions, we will uncover ways to inhibit them and provide a foundation for developing a range of therapeutics.