Molecular basis and inhibition of TIR-domain function in Toll-like receptor and neuronal cell-death pathways

Toll 样受体和神经元细胞死亡途径中 TIR 结构域功能的分子基础和抑制

• 批准号: nhmrc : GNT1160570
• 金额: $ 77.25万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-inhibition-death-pathways/1379133
• 关键词: Molecular; basis; inhibition; TIR; domain

A protein domain called TIR domain plays key roles in signalling in innate immunity pathways, associated with chronic inflammatory diseases, and the axon degeneration pathway, a pathway central to neurodegenerative disorders. We found that TIR domains form large assemblies and at least in some cases possess enzymatic activity. Through characterizing the molecular details of these functions, we will uncover ways to inhibit them and provide a foundation for developing a range of therapeutics.

称为TIR结构域的蛋白质结构域在与慢性炎性疾病相关的先天免疫途径和神经退行性疾病的中枢途径轴突变性途径中的信号传导中起关键作用。我们发现TIR结构域形成大的组装体，并且至少在某些情况下具有酶活性。通过表征这些功能的分子细节，我们将揭示抑制它们的方法，并为开发一系列治疗方法提供基础。