3D Shape Correspondence Quantification of Surgical Outcomes

描述（由申请人提供）：颅面畸形是所有出生缺陷中最常见的，有1- 2%的美国人口有严重的畸形，足以致残或污名化。外科手术继续发展，以减少这些疾病的严重功能和社会心理影响。但大多数治疗方法都没有得到系统的评估，而且由于各种原因，许多治疗方法永远无法在随机临床试验中得到评估。术后生理适应的观察性研究表明，纵向评估同样重要。然而，由于缺乏纵向数据三维定量评估的计算和分析工具，外科医生评估复杂颅面矫正手术的能力受到阻碍。利用颅底表面注册纵向锥束CT扫描的图像分析系统是使3D扫描在临床上有用的第一步。在这个建议中，我们正在验证和应用一个新的模型来量化颅面畸形手术的结果。使用最先进的图像分析方法，由于手术矫正和术后重塑的区域骨骼变化将被量化。我们的多学科团队完全有资格实现这些目标。这项工作将为未来三维计算机模拟在诊断和手术治疗计划以及新治疗方法的结果评估方面的研究应用提供初步数据。公共卫生相关性：颅面畸形是所有出生缺陷中最常见的，美国人口中有1- 2%的人患有严重到足以致残或污名化的畸形。外科手术继续发展，以减少这些疾病的严重功能和社会心理影响。然而，由于缺乏纵向数据三维定量评估的计算和分析工具，外科医生评估复杂颅面矫正手术的能力受到阻碍。在这个建议中，我们正在验证和应用一个新的模型来量化颅面畸形手术的结果。这项工作将为未来三维计算机模拟在诊断和手术治疗计划以及新治疗方法的结果评估方面的研究应用提供初步数据。

DESCRIPTION (provided by applicant): Craniofacial deformities are among the most common of all birth defects, with 1- 2% of the US population having a deformity severe enough to be disabling or stigmatizing. Surgical procedures continue to be developed to reduce the serious functional and psychosocial effects of these conditions. But most procedures have not been assessed in a systematic way, and for a variety of reasons, many could never be assessed in a randomized clinical trial. Observational studies of the physiologic adaptations post-surgery have indicated that longitudinal assessments are as important. However, the surgeon's ability to assess complex corrective craniofacial procedures has been hampered by the lack of computational and analytical tools for 3D quantitative evaluation of longitudinal data. An image analysis system to register longitudinal Cone-Beam CT scans using the surface of the cranial base is a first step in the process of making 3D scans clinically useful. In this proposal, we are validating and applying a new model to quantify craniofacial deformity surgical outcomes. Using state of the art image analysis methods, regional skeletal changes due to surgical correction and post-surgical remodeling will be quantified. Our multidisciplinary team is well qualified to address these aims. This work will provide preliminary data for future research applications on 3D computer simulation for diagnosis and surgical treatment planning, and for outcome assessments of new treatment procedures. Public Health Relevance: Craniofacial deformities are among the most common of all birth defects, with 1- 2% of the US population having a deformity severe enough to be disabling or stigmatizing. Surgical procedures continue to be developed to reduce the serious functional and psychosocial effects of these conditions. However, the surgeon's ability to assess complex corrective craniofacial procedures has been hampered by the lack of computational and analytical tools for 3D quantitative evaluation of longitudinal data. In this proposal, we are validating and applying a new model to quantify craniofacial deformity surgical outcomes. This work will provide preliminary data for future research applications on 3D computer simulation for diagnosis and surgical treatment planning, and for outcome assessments of new treatment procedures.