Molecular basis of T cell Receptor bias in viral immunity

病毒免疫中 T 细胞受体偏向性的分子基础

• 批准号: nhmrc : 508929
• 负责人: Dr Craig Clements
• 金额: $ 36.01万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-basis-t-viral-immunity/98568
• 关键词: Molecular; basis; cell; Receptor; bias

Viral infection results in the activation and proliferation of T cells that eradicate infected cells. Recognition of infected cells is meditated by presentation and recognition of viral protein fragments via specific cell surface receptors. This proposal plans to examine the factors that determine the diversity of the immune response and the consequences of such diversity on anti-viral immunity. This has implications for the development of vaccines.

病毒感染导致T细胞的活化和增殖，从而根除受感染的细胞。感染细胞的识别通过特异性细胞表面受体呈递和识别病毒蛋白片段来调节。该提案计划研究决定免疫反应多样性的因素以及这种多样性对抗病毒免疫的后果。这对疫苗的开发有影响。