Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity

多环芳烃毒性机制

• 批准号: 7650253
• 负责人: Darryl Brice Hood
• 金额: $ 73.1万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-18 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7650253
• 关键词: Mechanisms; Polycyclic; Aromatic; Hydrocarbon; Toxicity

DESCRIPTION (provided by applicant): This revised ARCH application proposes a project between Meharry Medical College, a historical black college/university (HBCU/MSI), and Vanderbilt University School of Medicine, a research intensive institution (RIU) that focuses on enhancing collaborations between investigators at these institutions in the general area of toxicology. The goal of this proposal is pursue hypothesis-driven research project grant programs in "Molecular Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity" at MMC in close collaboration with faculty at Vanderbilt University School of Medicine. This arrangement is designed to allow the accomplishment of the following Specific Aims. Specific Aim 1 is to develop the research programs of ARCH faculty as measured by joint, impact publications between MMC-VU research teams by the midpoint of the second year of this initiative. Specific Aim 2 is to develop the research programs of ARCH faculty in a way that fosters the launching of the independent careers of these investigators, as measured by successful acquisition of peer-reviewed funding. The strengths and resources of both institutions have been merged so as to create a joint project that is expected to increase the success rate of research project grant applications by Meharry faculty members to the National Institutes of Environmental Health Sciences (NIEHS). This revised application comprises three main components: 1) the Administrative and Planning Core will be responsible for managing and monitoring the entire project. The administrative core will receive guidance from internal and external advisory committees. 2) The research program development core will consist of three pilot projects and one research project conducted by MMC investigators. The pilot and research projects establish close collaborations between investigators from MMC and Vanderbilt University School of Medicine. 3) A well-integrated facility core is requested to support the ARCH investigators. Over the tenure of the proposed project, these three components will develop into a cohesive program of environmental health science research. The research described in this revised application uses exposure to "B[a]P" as a model to understand the etiology of neurological dysfunction and cancer. REVIEW OF ADMINISTRATIVE PLANNING CORE DESCRIPTION (provided by applicant) The Administrative and Planning core will manage and monitor the progress of this program. Specific objectives for this core will be to provide leadership that will assure the scientific growth and professional development of the MMC investigators; to ensure effective collaboration between MMC scientists and VUMC scientists; to foster an enhanced MMC/VUMC partnership in toxicological training and research by organizing team meetings, seminar series, and relevant workshops, and an annual toxicology symposium; to provide effective management of the ARCH program administratively and fiscally. This core will be directed by Drs Hood, the principal investigator from MMC, and Aschner from VUMC. Both the Internal and External Advisory Committees will offer guidance to the directors of this core. The administrative mechanism that supports this scientific collaboration is straightforward in that the principal investigator is responsible for overall direction of the project while the project leader at the RIU is charged in managing the projects conducted at VUMC. Leadership responsibilities will be shared by the principal investigator at MCC and the RIU leader at VUMC. Operations at the two Institutions will be integrated as a result of the advisory committees, seminars, and other interactive mechanisms.

描述(由申请人提供)： 这一修订的ARCH申请提出了一个项目，该项目是梅哈里医学院和范德比尔特大学医学院之间的项目，梅哈里医学院是一所历史悠久的黑人学院/大学(HBCU/MSI)，范德比尔特大学医学院是一家研究密集型机构(RIU)，专注于加强这些机构的研究人员在毒理学一般领域的合作。这项建议的目标是与范德比尔特大学医学院的教员密切合作，在MMC的“多环芳香烃毒性的分子机制”中开展假说驱动的研究项目资助计划。这一安排旨在实现以下具体目标。具体目标1是制定ARCH教员的研究计划，通过MMC-VU研究小组之间的联合影响出版物来衡量，到本倡议第二年的中点。具体目标2是制定ARCH教员的研究计划，以促进这些研究人员启动独立职业生涯，以成功获得同行审查的资金为衡量标准。这两个机构的优势和资源已被合并，以创建一个联合项目，预计将提高Meharry教职员工向国家环境健康科学研究所(NIEHS)申请研究项目拨款的成功率。经修订的申请包括三个主要部分：1)行政和规划核心将负责管理和监测整个项目。行政核心将接受内部和外部咨询委员会的指导。2)研究项目开发核心将由三个试点项目和一个由MMC调查人员进行的研究项目组成。试点和研究项目在MMC和范德比尔特大学医学院的研究人员之间建立了密切的合作。3)要求有一个完整的设施核心来支持ARCH调查员。在拟议的项目期限内，这三个组成部分将发展成为一个连贯的环境健康科学研究计划。在这份修订后的申请中描述的研究使用暴露于“苯并[a]磷”作为模型来理解神经功能障碍和癌症的病因。 对行政规划核心的审查 描述(由申请人提供) 行政和规划核心将管理和监测该方案的进展情况。这一核心的具体目标将是提供领导力，确保MMC研究人员的科学成长和专业发展；确保MMC科学家与VUMC科学家之间的有效合作；通过组织团队会议、研讨会系列、相关研讨会和年度毒理学专题讨论会，促进MMC/VUMC在毒理学培训和研究方面的强化伙伴关系；在行政和财政上有效管理ARCH计划。这个核心将由MMC的首席研究员DRS Hood和VUMC的Aschner指导。内部和外部咨询委员会都将向这一核心的主任提供指导。支持这一科学协作的行政机制很简单，因为首席调查员负责项目的总体指导，而RIU的项目负责人负责管理在VUMC进行的项目。领导责任将由MCC的首席调查员和VUMC的RIU领导人分担。由于咨询委员会、研讨会和其他互动机制，两个机构的业务将整合在一起。