CORE--ARCH Facility
核心--拱门设施
基本信息
- 批准号:7161191
- 负责人:
- 金额:$ 14.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-07-01 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The long-term objectives of the proposed Meharry Medical College ARCH Facility Core is to augment and
expand the capacity of the existing Inhalation Toxicology Facility and the Environment Toxicology laboratory
to perform B(a)P exposures, both inhalation and oral, and to assess tissue deposition of the toxin and
metabolites. Doing so will enable better quality control, while reducing costs to the individual investigator
and in case of the ARCH Program will facilitate the understanding of the molecular mechanism of B(a)P
toxicity. The Short term aims are: 1) To provide a well-integrated facility core to provide for the purchase,
exposure, animal husbandry and analysis of B (a) P parent compound/ metabolites from each organ system
under study in each ARCH research/pilot project, and 2) To continually enhance and refine technology. As
an example, we are exploring introducing state-of-the-art single-cell nanobiosensor technology for the
analysis of B(a)P metabolites in single cells or small cell groups, for future studies by our investigators.
The Inhalation Toxicology Facility is Directed by the PD, Dr. Darryl Hood, while an ARCH investigator, Dr.
Aramandla Ramesh, directs the Environmental Toxicology laboratory. Both of the investigators have
extensive experience relative to their responsibility to this core.
Mice models will be used to exploit the use of transgenic mice when appropriate so as to allow for the
development of a more mechanistic approach in all projects. For example, Dr. Ramesh and Dr. Morrow are
testing the hypothesis that B (a) P exposure will accelerate the progression of colon cancer using the Pac
Min+/- transgenic mouse model. Similarly, the hypothesis of Drs. Ogunkua and Matusik is that B(a)P
exposure will shift the dose-response curve to the left with respect to the progression from pre-neoplastic foci
to the adenocarcinoma in the 12t-7f transgenic LADY mouse model. Drs. Ansah and Deutch will employ the
use of C57BL/6J mice, as this will offer them the opportunity to test their hypothesis in transgenic mice that
overexpress antioxidant enzymes. In the case of the Hood/Aschner project, the shift from rats to mice will
allow for the of transgenic mouse models which has a "built in" advantage for future studies that will use +/-
and -/- knockouts on this C57BL background.
拟议的梅哈里医学院ARCH设施核心的长期目标是增加和
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Darryl Brice Hood其他文献
Darryl Brice Hood的其他文献
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{{ truncateString('Darryl Brice Hood', 18)}}的其他基金
Mechanisms of Inhaled B(a)P-Induced Neurotoxicity
吸入苯并芘引起的神经毒性机制
- 批准号:
8136411 - 财政年份:2010
- 资助金额:
$ 14.55万 - 项目类别:
RESEARCH PROJECT: "Mechanisms of B(a)P Induced Neurotoxicity"
研究项目:“B(a)P 诱导神经毒性的机制”
- 批准号:
8106197 - 财政年份:2010
- 资助金额:
$ 14.55万 - 项目类别:
Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity
多环芳烃毒性机制
- 批准号:
7475137 - 财政年份:2006
- 资助金额:
$ 14.55万 - 项目类别:
Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity
多环芳烃毒性机制
- 批准号:
7904299 - 财政年份:2006
- 资助金额:
$ 14.55万 - 项目类别:
Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity
多环芳烃毒性机制
- 批准号:
7650253 - 财政年份:2006
- 资助金额:
$ 14.55万 - 项目类别:
RESEARCH PROJECT: "Mechanisms of B(a)P Induced Neurotoxicity"
研究项目:“B(a)P 诱导神经毒性的机制”
- 批准号:
7161190 - 财政年份:2006
- 资助金额:
$ 14.55万 - 项目类别:
Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity
多环芳烃毒性机制
- 批准号:
7150918 - 财政年份:2006
- 资助金额:
$ 14.55万 - 项目类别:
Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity
多环芳烃毒性机制
- 批准号:
7287796 - 财政年份:2006
- 资助金额:
$ 14.55万 - 项目类别:
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