Novel Glaucoma Diagnostics for Structure and Function

新型青光眼结构和功能诊断

• 批准号: 7674649
• 负责人: Joel S Schuman
• 金额: $ 46.48万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7674649
• 关键词: Address; Axon; Biological; Boston; Characteristics; Clinical; Computers; Contralateral; Data; Detection; Devices; Diagnostic; Discrimination; Early Diagnosis; Engineering; Enrollment; Evaluation; Eye; Funding; Future; Glaucoma; Image; Imaging Device; Imaging technology; Institutes; Lasers; Lead; Massachusetts; Measurement; Measures; Medical center; Nerve Fibers; New England; Onset of illness; Ophthalmologist; Ophthalmoscopy; Optic Disk; Optic Nerve; Optical Coherence Tomography; Participant; Patients; Perimetry; Process; Reproducibility; Research; Research Design; Research Priority; Research Project Grants; Resolution; Retinal; Retinal Ganglion Cells; Scanning; Scientist; Speed; Staging; Structure; Subgroup; Suspect Glaucomas; Techniques; Technology; Testing; Tissues; Translational Research; Treatment Effectiveness; Universities; Vision; Vision research; Visual Fields; Visual evoked cortical potential; base; cohort; density; eye center; follow-up; image registration; improved; indexing; instrument; macula; medical schools; member; multidisciplinary; neuronal cell body; novel; optic nerve disorder; polarimetry; prospective; prototype; research and development; research study; retinal nerve fiber layer; technology development

DESCRIPTION: Our broad, long term objective continues to be the development of technologies for precisely measuring optic nerve and retinal changes that will enable early detection of glaucoma and of glaucoma progression. This translational research project is a collaborative effort of our multidisciplinary team of ophthalmologists, engineers, computer scientists and physicists at the University of Pittsburgh, Tufts University School of Medicine, Massachusetts Institute of Technology and Carnegie Mellon University. Our Specific Aims are (1) To detect the earliest possible evidence of glaucomatous damage and progression through objective, quantitative structural and functional assessment. We will compare ocular structural measurements (OCT, CSLO, SLP) and ocular function measurements (perimetry and multifocal visual evoked potential) using the historical and prospective examinations on the subgroups in our long-term longitudinal Boston cohort and new longitudinal prospective examinations on our Pittsburgh cohort. We expect that changes detected with structural measures will precede those detected with functional techniques. (2) To determine whether a synergistic index of correspondence, that combines structural and perimetric data, accelerates the ability to detect perimetric abnormality or progression in glaucoma. This prospective experiment will evaluate the ability of combined structural and functional correspondence indices to reliably predict visual field results in early to moderate glaucoma patients. Such an index could reduce or eliminate the need for confirmatory perimetric testing in the future and (3) To advance micron-scale tomographic imaging using OCT measurement technology for early detection of glaucoma and for more sensitive discrimination of progression. A new, high speed, high resolution instrument that we have developed provides about 1-3 mu m axial resolution at 16,000 axial scans per second. We will evaluate in healthy, suspect and glaucomatous subjects the ability of this and other technologic strategies that we are developing - including, tracking-OCT and spectral-domain-OCT - to provide even better image registration, measurement reproducibility and discriminating power. This project addresses the Strategic Research Priorities stated in the National Plan for Vision Research, to ".. .develop improved diagnostic measures to detect optic nerve disease onset, progression, and treatment effectiveness."

产品说明：我们广泛的长期目标仍然是开发用于精确测量视神经和视网膜变化的技术，从而能够早期检测青光眼和青光眼进展。这个转化研究项目是我们多学科团队的合作成果，包括匹兹堡大学、塔夫茨大学医学院、马萨诸塞州理工学院和卡内基梅隆大学的眼科医生、工程师、计算机科学家和物理学家。我们的具体目标是：（1）通过客观、定量的结构和功能评估，尽早发现脑损伤和进展的可能证据。我们将使用长期纵向波士顿队列中亚组的历史和前瞻性检查以及匹兹堡队列中新的纵向前瞻性检查来比较眼结构测量（OCT、CSL 0、SLP）和眼功能测量（视野检查和多焦视觉诱发电位）。我们预计，结构措施检测到的变化将先于功能技术检测到的变化。(2)确定是否协同一致性指数，结合结构和周长数据，加速检测青光眼周长异常或进展的能力。这项前瞻性实验将评估结构和功能对应指数联合可靠预测早期至中度青光眼患者视野结果的能力。这样的指数可以减少或消除未来对确认性视野检查的需要，以及（3）使用OCT测量技术推进微米级断层成像，以早期检测青光眼并更灵敏地区分进展。我们开发的一种新的高速高分辨率仪器在每秒16，000次轴向扫描时提供约1-3 μ m的轴向分辨率。我们将在健康、可疑和昏迷的受试者中评估我们正在开发的这种和其他技术策略的能力-包括跟踪OCT和谱域OCT -以提供更好的图像配准、测量再现性和鉴别能力。该项目涉及国家视力研究计划中规定的战略研究优先事项，以“. .开发改进的诊断措施来检测视神经疾病的发作、进展和治疗效果。"