Animal Behavioral Phenotyping

补充和替代医学研究英才中心的总体目标 (CERC)在阿尔茨海默病中的应用是鉴定具有生物活性的葡萄多酚在预防AD中的作用 和/或治疗阿尔茨海默病A型AP小鼠模型的神经病理和认知功能 恶化。该中心的总体研究活动将探索葡萄多酚 Tg2576中化合物对减轻阿尔茨海默病类型认知恶化的潜在作用 通过减少小鼠脑内可溶性胞外寡聚体A|3的积聚。在此基础上 考虑到，核心C(鼠标表型核心)的目的是直接支持整个中心 通过促进对Tg2576小鼠认知功能的表征来响应 葡萄汁/葡萄酒中的多酚制剂(项目1)葡萄源多酚白藜芦醇 (项目2)和葡萄籽提取物多酚制剂(项目3)。在认识到多个 认知和行为模式有助于高等动物的整体认知功能状态， 包括人类和AO小鼠模型，Core C将使用多种行为范式来提供更多 全面、灵敏地测量多酚治疗后认知功能的变化。 因此，核心C的活动将把个别项目的具体目标与 这是CERC在阿尔茨海默病中的应用。CERC在阿尔茨海默病方面的集体努力 将为开发单独或组合的葡萄多酚提供合理的依据 通过调节一个或多个AD相关分子来预防和/或治疗阿尔茨海默病的化合物 机械装置。

The overall objective of this Center of Excellence for Research on Complementary and Alternative Medicine (CERC) in Alzheimer's disease application is to identify bioactive grape-derived polyhenols in AD prevention and/or therapy in the Tg2576 mouse model of Alzheimer's disease-type Ap neuropathology and cognitive deterioration. The overall research activities in this Center will explore grape-derived polyphenolic compounds for their potential roles of reduce Alzheimer's disease type cognitive deterioration in Tg2576 mice by reducing the accumulation of soluble extracellular oligomeric A|3 species in the brain. Based on this consideration, the purpose of Core C (Mouse Phenotyping Core) is to directly support the overall Center effort by facilitating the characterization of cognitive functions in Tg2576 mice in response to treatments with polyphenolic preparations from grape juice/wine (Project 1), the grape-derived polyphenolic, resveratrol (Project 2) and polyphenolic preparations from grape seed extract (Project 3). In recognition that multiple cognitive and behavioural modalities contribute to the overall cognitive functional status in higher animals, including human and AO mouse models, Core C will use multiple behavioural paradigms to provide a more comprehensive and sensitive measure of changes cognition function in response to polyphenolic treatments. Thus, the activity of Core C will integrate the specific goals of individual projects with the overall objective of this CERC in Alzheimer's disease application. The collective effort from the CERC in Alzheimer's disease will provide the rational basis for developing individual or a combination of grape-derived polyphenolic compounds for Alzheimer's disease prevention and/or therapy by modulating one or more of the AD-related mechanisms.