Molecular characterisation of the dendritic cell receptor Clec9a and its ligand interactions
Molecular characterisation of the dendritic cell receptor Clec9a and its ligand interactions
树突状细胞受体 Clec9a 的分子特征及其配体相互作用
批准号：
nhmrc : 1025201
负责人：
A/Pr Mireille Lahoud
金额：
$43.46万
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2012
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2012-01-01 至 2014-12-31
中文摘要
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英文摘要
The immune system senses danger from infectious diseases, damaged and dead cells. We identified a danger receptor, Clec9A, on a specialised cell type of the immune system in mice and humans. Clec9A recognizes and induces immunity to dangerous dead cells. Delivering vaccines to Clec9A improves vaccine responses. We will investigate how Clec9A recognises and reacts to danger, and how we can mimic this recognition to improve vaccine design.
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会议论文
Boosting effectiveness of new vaccines for dengue ,HFMD and influenza by targeting vaccine antigens to Clec9A on dendritic cells.
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批准号：nhmrc : 1056401
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项目类别：Targeted Calls
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资助金额：$26.43万
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财政年份：2013
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负责人：A/Pr Mireille Lahoud
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依托单位：
海外基金
