Molecular Characterisation of Clathrin-independent Endocytosis in Migrating Cells

细胞迁移是胚胎发育中涉及的生理过程以及癌症转移等疾病的基本特征。细胞运动需要细胞表面发生广泛的变化。我们已经确定了一个重要的途径参与细胞迁移过程中的膜贩运。该提案旨在鉴定参与该途径的细胞组分，筛选新的抑制剂，并确定该途径在迁移癌细胞中的作用。

Cell migration is an essential feature of physiological processes involved in embryo development, as well as disease conditions such as cancer metastasis. Cell movement requires extensive changes to the cell surface. We have identified a vital pathway involved in membrane trafficking during cell migration. This proposal aims to identify the cellular components involved in this pathway, screen for new inhibitors, and characterise the role of this pathway in migrating cancer cells.