Catalytic Asymmetric Oxidation: Easy Entry to Highly Functionalized Molecules

催化不对称氧化:轻松进入高功能化分子

基本信息

  • 批准号:
    7666017
  • 负责人:
  • 金额:
    $ 33.06万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-09-01 至 2011-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Project summary: Modern drugs are highly functionalized molecules, and often these molecules are chiral. The most promising solution for production of these molecules has relied on an asymmetric catalytic process, especially catalytic asymmetric oxidation, which can introduce multi functional groups into the molecule. The long-term goal is to develop catalytic asymmetric oxidation processes which can create highly functionalized drugs at a useful level of selectivity and scalability. The objective of developing these catalysts is to provide reliable and easy access to make molecules previously unattainable in a simple manner. The key to success is proper molecular design of an oxidation catalyst. Catalytic selective oxidation can introduce oxygen, nitrogen, and halogen to the substrate catalytically and selectively. Guided by strong preliminary data, this hypothesis will be tested by pursuing four specific aims: 1) asymmetric construction of quaternary carbon using nitroso chemistry, 2) development of catalytic asymmetric nitroso hetero-Diels-Alder and related asymmetric cycloadditions, 3) asymmetric epoxidation and its kinetic resolution, and 4) asymmetric halogenation. All four approaches are innovative, because each of them is an unknown process which capitalizes on a totally new concept of catalyst design developed by our group using earlier NIH support. They also take advantage of a number of ligand libraries which are available in no other laboratory. The proposed research is significant, because it is expected to provide a fine toolbox of catalysts, which will make possible the provision of previously unattainable complex molecules needed to develop entirely new pharmacologic strategies in the future. Relevance to Public Health: This is an important area of organic synthesis that has potential applicability to efficiently strengthen drugs, ultimately including those for human beings. Finally, the projects described herein will provide excellent training for graduate students and postdoctoral associates in catalysis, experience that will prepare them well for independent research careers to contribute for public health.
项目概述:现代药物是高度功能化的分子,这些分子通常是手性的。生产这些分子最有希望的解决方案依赖于不对称催化过程,特别是催化不对称氧化,它可以在分子中引入多个官能团。长期目标是发展催化不对称氧化过程,可以在选择性和可扩展性的有用水平上创造高度功能化的药物。开发这些催化剂的目的是提供可靠和容易的途径,以简单的方式使以前无法获得的分子。成功的关键在于氧化催化剂的分子设计。催化选择性氧化可以催化和选择性地将氧、氮和卤素引入底物。在强有力的初步数据指导下,这一假设将通过四个具体目标进行验证:1)利用亚硝基化学不对称构造季碳;2)催化不对称亚硝基杂diels - alder及其不对称环加成的发展;3)不对称环氧化及其动力学拆分;4)不对称卤化。所有这四种方法都是创新的,因为它们中的每一个都是一个未知的过程,它利用了我们小组在早期NIH支持下开发的催化剂设计的全新概念。它们还利用了许多其他实验室所没有的配体库。这项提议的研究意义重大,因为它有望提供一个精细的催化剂工具箱,这将使提供以前无法获得的复杂分子成为可能,这些分子需要在未来开发全新的药理学策略。与公共卫生的相关性:这是有机合成的一个重要领域,可能适用于有效强化药物,最终包括人用药物。最后,本文所述的项目将为研究生和博士后提供催化方面的优秀培训,经验将为他们的独立研究事业做好准备,为公共卫生做出贡献。

项目成果

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HISASHI None YAMAMOTO其他文献

HISASHI None YAMAMOTO的其他文献

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{{ truncateString('HISASHI None YAMAMOTO', 18)}}的其他基金

Catalytic Asymmetric Oxidation: Easy Entry to Highly Functionalized Molecules
催化不对称氧化:轻松进入高功能化分子
  • 批准号:
    8011916
  • 财政年份:
    2010
  • 资助金额:
    $ 33.06万
  • 项目类别:
Catalytic Asymmetric Oxidation: Easy Entry to Highly Functionalized Molecules
催化不对称氧化:轻松进入高功能化分子
  • 批准号:
    7314350
  • 财政年份:
    2003
  • 资助金额:
    $ 33.06万
  • 项目类别:
Catalytic Asymmetric Oxidation: Easy Entry to Highly Functionalized Molecules
催化不对称氧化:轻松进入高功能化分子
  • 批准号:
    8466983
  • 财政年份:
    2003
  • 资助金额:
    $ 33.06万
  • 项目类别:
Asymmetric Synthesis Using N-O Compounds.
使用 N-O 化合物的不对称合成。
  • 批准号:
    6945732
  • 财政年份:
    2003
  • 资助金额:
    $ 33.06万
  • 项目类别:
Asymmetric Synthesis Using N-O Compounds
使用 N-O 化合物的不对称合成
  • 批准号:
    6666571
  • 财政年份:
    2003
  • 资助金额:
    $ 33.06万
  • 项目类别:
Asymmetric Synthesis Using N-O Compounds.
使用 N-O 化合物的不对称合成。
  • 批准号:
    7121536
  • 财政年份:
    2003
  • 资助金额:
    $ 33.06万
  • 项目类别:
Asymmetric Synthesis Using N-O Compounds.
使用 N-O 化合物的不对称合成。
  • 批准号:
    6795583
  • 财政年份:
    2003
  • 资助金额:
    $ 33.06万
  • 项目类别:
Catalytic Asymmetric Oxidation: Easy Entry to Highly Functionalized Molecules
催化不对称氧化:轻松进入高功能化分子
  • 批准号:
    8283752
  • 财政年份:
    2003
  • 资助金额:
    $ 33.06万
  • 项目类别:
Catalytic Asymmetric Oxidation: Easy Entry to Highly Functionalized Molecules
催化不对称氧化:轻松进入高功能化分子
  • 批准号:
    7491593
  • 财政年份:
    2003
  • 资助金额:
    $ 33.06万
  • 项目类别:

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