CB: Biostatistics Core

CB：生物统计学核心

• 批准号: 7510970
• 负责人: Mariza de ANDRADE
• 金额: $ 11.64万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7510970
• 关键词: Address; Affect; Archives; Area; Arts; Basic Science; Bioinformatics; Biostatistics Core; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Compatible; Complement; Complex; Consultations; Correlative Study; Country; Data; Data Analyses; Data Collection; Data Quality; Data Set; Databases; Development; Ensure; Epidemiologic Studies; Experimental Designs; Funding; Gene Mutation; Genes; Goals; Human Resources; Image; Immunologics; Individual; Information Management; Link; Logistics; Malignant neoplasm of pancreas; Manuscripts; Methodology; Mind; Modeling; Molecular; Nature; Operative Surgical Procedures; Outcome Measure; Population; Preparation; Probability; Procedures; Process; Program Development; Program Research Project Grants; Protocols documentation; Quality Control; Randomized; Range; Relative (related person); Reproduction spores; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Sample Size; Sampling; Scheme; Services; Specific qualifier value; Staging; Statistical Models; Support of Research; System; Testing; Time; Tissues; Translational Research; Valid Value; Work; Writing; abstracting; career; comparison group; data management; data modeling; design; experience; innovation; member; patient registry; research study; tissue registry

The Biostatistics Core (BC) provides statistical collaboration and data management support for each of the SPORE projects, the Developmental Research Program projects, the Career Development Program, and the other Cores. In the past funding period, the BC supported research, and established the infrastructure to link the Tissue and Patient Registry Cores. For this competitive renewal, the BC prepared the statistical plans for each of the four Projects, will provide data management for each of the projects, and will prepare data summaries for manuscript preparation. Each of the projects presented in this application reflects input from members of the BC on study design, and analysis plan. These projects span a wide range of approaches and analyses required. The BC builds upon the innovative and time-tested procedures and systems developed by Mayo Clinic, one of the largest statistical groups in the country whose members have collaborated on more than 10,000 clinical and basic science research studies since 1966. The BC has capability to provide statistical support across different fields, including molecular epidemiologic studies, basic science with translational, immunologic, and correlative studies, gene microarray and imaging, clinical trials, gene and mutation discovery, and information management. The comprehensive nature of the BC assures each SPORE investigator access to statistical expertise that includes collaborative development of study designs and analysis plans, state-of-the-art data analysis and interpretation, data management resources, and abstract and manuscript preparation. The BC also provides a mechanism for the management and integration of both existing and newly collected data through consistent and compatible data handling. Areas of support include database development, data form development and processing, data collection and entry, data archiving, quality control, and management of information relating to the projects and cores. This Core complements and assists the efforts of the Clinical Research and Tissue Cores by providing superior data management and experience with tissue registries. The strengths of the BC are our collaboration with each of the projects and cores, the ability to utilize the established centralized research database, the operational and statistical infrastructure already in place in the SPORE, and the breadth of expertise provided by BC personnel.

生物统计学核心（BC）为每个国家提供统计协作和数据管理支持。 SPORE项目、发展研究计划项目、职业发展计划和 其他核心在过去的资助期间，不列颠哥伦比亚省支持研究，并建立了基础设施， 组织和患者注册中心。对于此次竞争性续约，BC编制了以下统计计划： 将为每个项目提供数据管理，并将准备数据 为手稿准备摘要。本应用程序中介绍的每个项目都反映了来自 研究设计和分析计划。这些项目涉及各种方法 所需的分析。业务连续性建立在创新和经过时间考验的程序和系统之上 由马约诊所开发，梅奥诊所是该国最大的统计小组之一，其成员拥有 自1966年以来，合作进行了10，000多项临床和基础科学研究。BC有 提供不同领域统计支持的能力，包括分子流行病学研究， 基础科学与转化，免疫学和相关研究，基因微阵列和成像，临床 试验、基因和突变发现以及信息管理。BC的综合性质 确保每个SPORE调查员都能获得统计专业知识，包括合作开发 研究设计和分析计划，最先进的数据分析和解释，数据管理 资源，摘要和手稿准备。此外，《巴塞尔公约》亦提供机制， 管理和整合现有的和新收集的数据， 数据处理支持领域包括数据库开发、数据表格开发和处理、数据 收集和输入、数据存档、质量控制和管理与项目有关的信息 和核心。该核心补充并协助临床研究和组织核心的工作， 提供上级数据管理和组织登记经验。不列颠哥伦比亚省的优势是我们的 与每个项目和核心的合作，利用现有的集中研究的能力 数据库、SPORE中已经到位的操作和统计基础设施，以及 BC人员提供的专业知识。