CB: Biostatistics Core

生物统计核心(BC)为以下各项提供统计协作和数据管理支持 孢子项目、发展研究计划项目、职业发展计划和 其他核心。在过去的资助期，BC支持研究，并建立了连接基础设施 组织和患者登记处的核心。为了这次竞争更新，BC准备了以下统计计划 四个项目中的每个项目都将为每个项目提供数据管理，并将准备数据 稿件准备工作总结。此应用程序中显示的每个项目都反映了来自 BC成员对研究设计、分析计划。这些项目涵盖了广泛的方法 以及所需的分析。BC建立在创新和经过时间考验的程序和系统的基础上 由梅奥诊所开发，梅奥诊所是美国最大的统计组织之一，其成员 自1966年以来，在10,000多项临床和基础科学研究方面进行了合作。公元前三年 能够提供跨不同领域的统计支持，包括分子流行病学研究， 基础科学，包括翻译、免疫学和相关研究、基因芯片和成像、临床 试验、基因和突变发现以及信息管理。公元前十年的综合性 确保每个孢子调查员都能获得统计专业知识，包括合作开发 研究设计和分析计划、最先进的数据分析和解释、数据管理 资源，以及摘要和手稿的准备。BC还提供了一个机制，用于 通过一致性和兼容性管理和集成现有数据和新收集的数据 数据处理。支持领域包括数据库开发、数据表单开发和处理、数据 与项目有关的信息的收集和录入、数据归档、质量控制和管理 和核心。这一核心通过以下方式补充和协助临床研究和组织核心的努力 提供卓越的数据管理和组织登记体验。卑诗省的长处在于我们 与每个项目和核心进行协作，能够利用已建立的集中研究 数据库，孢子中已有的业务和统计基础设施，以及 BC人员提供的专业知识。

The Biostatistics Core (BC) provides statistical collaboration and data management support for each of the SPORE projects, the Developmental Research Program projects, the Career Development Program, and the other Cores. In the past funding period, the BC supported research, and established the infrastructure to link the Tissue and Patient Registry Cores. For this competitive renewal, the BC prepared the statistical plans for each of the four Projects, will provide data management for each of the projects, and will prepare data summaries for manuscript preparation. Each of the projects presented in this application reflects input from members of the BC on study design, and analysis plan. These projects span a wide range of approaches and analyses required. The BC builds upon the innovative and time-tested procedures and systems developed by Mayo Clinic, one of the largest statistical groups in the country whose members have collaborated on more than 10,000 clinical and basic science research studies since 1966. The BC has capability to provide statistical support across different fields, including molecular epidemiologic studies, basic science with translational, immunologic, and correlative studies, gene microarray and imaging, clinical trials, gene and mutation discovery, and information management. The comprehensive nature of the BC assures each SPORE investigator access to statistical expertise that includes collaborative development of study designs and analysis plans, state-of-the-art data analysis and interpretation, data management resources, and abstract and manuscript preparation. The BC also provides a mechanism for the management and integration of both existing and newly collected data through consistent and compatible data handling. Areas of support include database development, data form development and processing, data collection and entry, data archiving, quality control, and management of information relating to the projects and cores. This Core complements and assists the efforts of the Clinical Research and Tissue Cores by providing superior data management and experience with tissue registries. The strengths of the BC are our collaboration with each of the projects and cores, the ability to utilize the established centralized research database, the operational and statistical infrastructure already in place in the SPORE, and the breadth of expertise provided by BC personnel.