GENETIC ANALYSIS OF ALOPECIA AREATA

斑秃，斑片状脱发，可进展到全头皮或 体毛脱落，影响1%-2%的人口。我们假设 斑秃是一种组织相容性基因座抗原 限制性T细胞介导的毛囊自身免疫反应 抗原或病毒感染由多种因素相互作用引起 可能导致产生特异性抗体的免疫反应基因 针对毛囊的抗体。斑秃与其他 自身免疫性疾病，在同卵双胞胎和家庭中。它是 与人类白细胞抗原等位基因和其他免疫相关基因相关 相互作用，以确定敏感性、抵抗力和持久性。 可能的病毒感染和对毛囊、黑素细胞的抗体， 角质形成细胞和内皮细胞的意义尚不清楚。我们的 目的：探讨斑秃的遗传机制。 家庭的目的是预防疾病、早期干预和 开发特定的疗法。我们建议：a)确定和 收集AA家族的DNA；b)确定 斑秃患者同时利用斑秃和斑秃的信息 人类白细胞抗原标志物与疾病的聚集和关联 关于患者的一些亲属受到影响的风险；c) 确定人类白细胞抗原区域中涉及的致病氨基酸 斑秃过程；d)确定多态标记 家系中与斑秃相关的遗传位点。至 完成目标我们将收集几个皮肤科的家庭 休斯顿的诊所。对于目标b和c，我们将应用MASC和单倍型 方法：研究方法。对于目标d，我们将使用参数和非参数链接。 方法：研究方法。

Alopecia Areata, patchy hair loss which may progress to total scalp or body hair loss, affects 1-2 percent of the population. We hypothesize that Alopecia Areata is an HLA (histocompatibility locus antigens) restricted, T cell mediated autoimmune reaction to hair follicle antigens or viral infection resulting from the interactions of multiple genes of immune response which may result in the production of specific antibodies to the hair follicle. Alopecia Areata occurs with other autoimmune diseases, in identical twins and in families. It is associated with HLA alleles and with other immune related genes that may interact to determine susceptibility, resistance, and persistence. Possible viral infection and antibodies to hair follicle, melanocytes, keratinocytes, and endothelial cells are of unknown significance. Our goal is to investigate the genetic mechanism of Alopecia Areata in families of the purpose of disease prevention, early intervention, and development of specific therapies. We propose: a) to identify and collect DNA from AA families; b) to determine the genetic models for Alopecia Areata by using the simultaneous information on both the aggregation and association of the HLA marker with the disease and also on the risk of being affected for some relatives of a patient; c) to identify disease-predisposing amino acids in the HLA region involved in the Alopecia Areata process; d) to identify polymorphic markers for genetic loci that are associated with Alopecia Areata in families. To accomplish aim a we will collect families from several dermatology clinics in Houston. For aims b and c we will apply MASC and haplotype methods. For aim d, we will use parametric and nonparametric linkage methods.