MOLECULAR MESSENGERS THAT UNDERLIE NEUROTOXIC AND OTHER ACTIONS OF DRUGS OF ABUSE

滥用药物产生神经毒作用和其他作用的分子信使

• 批准号: 7640680
• 负责人: SOLOMON H. SNYDER
• 金额: $ 137.45万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7640680
• 关键词: Acetylesterase; Area; Bilirubin; Biliverdin reductase; Binding; Brain; Calcium; Calmodulin; Cell Death; Cells; Corpus striatum structure; Cyclic AMP-Dependent Protein Kinases; Cytosol; D Aspartate; EP300 gene; Glucocorticoids; Glutamates; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Heme; Histone Deacetylase; Investigation; Iron; Knockout Mice; Link; Lipids; Localized; Mediating; Mediator of activation protein; Membrane; Molecular; Mus; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; Neuromodulator; Neurons; Nicotinamide adenine dinucleotide; Nitric Oxide; Nuclear Translocation; Oxygenases; PTGS2 gene; Phosphorylation; Physiological; Play; Process; Progress Reports; Property; Prostaglandins; Proteins; Receptor Activation; Regulation; Research; Role; SLC11A2 gene; Scaffolding Protein; Signal Transduction; Stress; System; TP53 gene; Thyroid Hormones; base; cellular longevity; cyclooxygenase 2; drug of abuse; heme oxygenase-2; neuroprotection; neurotoxic; neurotoxicity; novel; oxidation; transmission process; uptake

Our proposal investigates molecular messengers that underlie neurotoxic and other actions of drugs of abuse. Specific areas covered in the research plan are neurotoxic influences of nitric oxide signaling, glyceraldehyde-3 -phosphate dehydrogenase and heme oxygenase/biliverdin reductase. Additionally, we will continue studies of D-aspartate as a neuromodulator and mediators of cell stress such as p53, areas which, for the sake of brevity, are detailed separately in the Progress Report.

我们的提案调查了神经毒性药物和其他药物作用的分子信使 虐待。研究计划涵盖的具体领域是一氧化氮信号传导的神经毒性影响， 3-磷酸​​甘油醛脱氢酶和血红素加氧酶/胆绿素还原酶。此外，我们将 继续研究 D-天冬氨酸作为神经调节剂和细胞应激介质（例如 p53），这些领域 为简洁起见，在进度报告中单独详细说明。