Developmental Projects

发展项目

• 批准号: 7490251
• 负责人: Carolyn C Meltzer
• 金额: $ 7.4万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490251
• 关键词: Area; Biohazardous Substance; Biomedical Engineering; Brain Neoplasms; Breast Cancer Early Detection; Cancer Patient; Certification; Data; Detection; Development; Dissection; Electronics; Faculty; Fostering; Funding; Future; Grant; Growth; IACUC; Image; Institutes; Interferon-alpha; Investments; Joints; K-Series Research Career Programs; Lead; Macaca mulatta; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Methodology; Methods; Mission; Modeling; Molecular; Monitor; Notification; Numbers; Optics; PK 11195; Pilot Projects; Preparation; Radiation; Radiology Specialty; Rattus; Research; Research Ethics Committees; Research Personnel; Research Project Grants; Resources; Safety; Scientist; Source; TNFRSF5 gene; Techniques; Tumor Suppressor Proteins; USA Georgia; Universities; Vision; Week; Western Asia Georgia; base; career; cone-beam computed tomography; molecular imaging; molecular/cellular imaging; nanoscale; programs; radiotracer; receptor; skills; tumor

An important component of the Emory Molecular and Translational Imaging Center (EMTIC) is the establishment of a strong pilot program to foster the continued growth of cancer-targeted molecular imaging research at Emory by bringing new investigators into EMTIC. Through the availability of Developmental Funds for Pilot Projects supported at the level of $35,000/year per pilot project, EMTIC will foster a steady source of new ideas, applications areas for new methodologies developed within the Cores, and opportunities for both trainees and established scientists to acquire preliminary data in the quantitative molecular imaging arena on which to base competitive future R01 proposals. Five outstanding pilot projects were selected following the solicitation of pilot proposals from all faculty affiliated with the Winship Cancer Institute (WCI) and those in the Departments of Radiology at Emory University and/or Biomedical Engineering at Georgia Tech. The Pilot Projects were chosen using the following review criteria: 1) scientific strengths, including likelihood to lead to R01 funding, 2} "fit" with the developing EMTIC vision, 3) was it potentially translational with a benefit to cancer patients, and 4) integration with institutional linkages and WCI programs. The Pilot Projects include: Pilot Project 1. Receptor-targeted Radiotracers for Detection of Pancreatic Cancer; Pilot Project 2. Optical Dissection of a Lung Cancer Tumor Suppressor; Pilot Project 3. Imaging Tumor HIF-1 Activity in a Rat Orthotopic Brain Tumor Model by MRI; Pilot Project 4, Identifying IFN-alpha-lnduced Microglial Activation Using C-11 PK11195 versus F-18 PK11195 in Rhesus Monkeys; and Pilot Project 5. Targeted "Triggerable" Nanoscale Contrast Enhanced Cone Beam Computed Tomography (CBCT) for Early Breast Cancer Detection. The Pilot Projects are highly integrated with both EMTIC Research Projects and Cores to benefit and contribute to the overall mission of this center grant.

埃默里分子和转化成像中心（EMTIC）的一个重要组成部分是 建立强有力的试点计划，以促进癌症靶向分子的持续增长， 在埃默里大学进行成像研究，将新的研究人员引入EMTIC。通过提供 试点项目发展基金，每个试点项目每年35 000美元， EMTIC将为新方法的开发和应用领域培养一个稳定的新思想来源 在核心内，为受训人员和知名科学家提供获得初步知识的机会， 定量分子成像竞技场中的数据，作为未来竞争性R 01提案的基础。 在向所有各方征求试点提案后，选出了五个优秀的试点项目 附属于Winship癌症研究所（WCI）和放射科的教师 或者格鲁吉亚理工学院的生物医学工程专业。 我们根据以下评审准则挑选试验计划：（1）科学实力，包括 可能导致R 01资金，2}“适合”发展中的EMTIC愿景，3）它是否可能 翻译与癌症患者的利益，以及4）与机构联系和WCI的整合 程序.试点项目包括：试点项目1。受体靶向放射性示踪剂用于检测 胰腺癌;试点项目2。肺癌肿瘤抑制剂的光学解剖 项目3。通过MRI成像大鼠原位脑肿瘤模型中的肿瘤HIF-1活性;试点项目 4.使用C-11 PK 11195与F-18 PK 11195在小鼠中鉴定IFN-α诱导的小胶质细胞活化。 恒河猴;和试点项目5。靶向“可触发”纳米级造影剂增强锥 电子束计算机断层扫描（CBCT）用于早期乳腺癌检测。试点项目包括 与EMTIC研究项目和核心高度集成， 本中心赠款的总体使命。