CORE--NEUROIMAGING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 神经成像核心将继续为ADRC调查人员进行的所有神经成像研究提供必要的支持。CORE在ADRC内有三重目标，它将继续追求：1)针对老化大脑体内研究中固有的独特挑战，开发和验证先进的结构和功能成像技术，2)开发和维护高分辨率结构磁共振成像(MRI)数据的体内“脑库”，以及3)支持未来成像研究人员的多学科培训，他们将解决神经退行性疾病特有的问题。在过去的资助期间，我们在新的核磁共振应用方面取得了实质性进展，包括与加州大学洛杉矶分校神经成像实验室和卡内基梅隆大学机器人研究所合作的创新形态测量技术，以及非侵入性动脉自旋标记核磁共振灌注成像的开发。由于正电子发射断层扫描(PET)技术的进步与ADRC的使命高度相关和支持，拟议的核心应用将扩大PET成像的作用，以涵盖正常衰老、轻度认知障碍和AD患者体内淀粉样蛋白负荷的量化。一系列神经成像工具的互补使用是由利用核心资源的调查人员之间的合作促进的。神经成像核心还高度致力于指导初级教师、博士后和博士后实习生验证先进的脑成像技术并将其转化为衰老和AD研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Neuroimaging Core will continue to provide the necessary support for all neuroimaging studies performed by ADRC investigators. The Core has had a tri-fold purpose within the ADRC, which it will continue to pursue: 1) methodological development and validation of advanced structural and functional imaging techniques targeting the unique challenges inherent in in vivo studies of the aging brain, 2) development and maintenance of an in vivo "brain bank" of high-resolution structural magnetic resonance imaging (MRI) data, and 3) providing support for the multidisciplinary training of future imaging researchers who will address questions specific to neurodegenerative disease. We have made substantial progress over the last funding period in novel MRI applications including innovative morphometric techniques in collaboration with the UCLA Laboratory of Neuroimaging and the Carnegie Mellon University Robotics Institute, and the development of non-invasive arterial spin-labeling MRI perfusion imaging. As a result of advances in positron emission tomography (PET) techniques highly relevant and supportive of the mission of the ADRC, the proposed Core application will expand the role of PET imaging to encompass in vivo quantification of amyloid load in normal aging, mild cognitive impairment, and AD. The complementary use of a range of neuroimaging tools is fostered by collaborations among investigators utilizing Core resources. The Neuroimaging Core is also highly committed to the mentoring of junior faculty, and pre- and post-doctoral trainees in the validation and translation of advanced brain imaging techniques to aging and AD research.