CORE--NEUROIMAGING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 神经影像学核心将继续为ADRC研究者进行的所有神经影像学研究提供必要的支持。核心小组在亚洲发展与和解委员会内有三重目标，并将继续努力：1）针对老化大脑的体内研究中固有的独特挑战，先进的结构和功能成像技术的方法学开发和验证，2）开发和维护高分辨率结构磁共振成像（MRI）数据的体内“大脑库”，以及3）为未来的成像研究人员的多学科培训提供支持，这些研究人员将解决神经退行性疾病的特定问题。在过去的资助期内，我们在新型MRI应用方面取得了重大进展，包括与UCLA神经成像实验室和卡内基梅隆大学机器人研究所合作的创新形态测量技术，以及非侵入性动脉自旋标记MRI灌注成像的开发。由于正电子发射断层扫描（PET）技术的进步与ADRC的使命高度相关并支持ADRC的使命，拟议的核心应用将扩大PET成像的作用，以涵盖正常衰老、轻度认知障碍和AD中淀粉样蛋白负荷的体内定量。利用核心资源的研究者之间的合作促进了一系列神经成像工具的互补使用。神经成像核心还高度致力于指导初级教师，以及博士前和博士后学员，以验证和翻译先进的脑成像技术，以老化和AD研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Neuroimaging Core will continue to provide the necessary support for all neuroimaging studies performed by ADRC investigators. The Core has had a tri-fold purpose within the ADRC, which it will continue to pursue: 1) methodological development and validation of advanced structural and functional imaging techniques targeting the unique challenges inherent in in vivo studies of the aging brain, 2) development and maintenance of an in vivo "brain bank" of high-resolution structural magnetic resonance imaging (MRI) data, and 3) providing support for the multidisciplinary training of future imaging researchers who will address questions specific to neurodegenerative disease. We have made substantial progress over the last funding period in novel MRI applications including innovative morphometric techniques in collaboration with the UCLA Laboratory of Neuroimaging and the Carnegie Mellon University Robotics Institute, and the development of non-invasive arterial spin-labeling MRI perfusion imaging. As a result of advances in positron emission tomography (PET) techniques highly relevant and supportive of the mission of the ADRC, the proposed Core application will expand the role of PET imaging to encompass in vivo quantification of amyloid load in normal aging, mild cognitive impairment, and AD. The complementary use of a range of neuroimaging tools is fostered by collaborations among investigators utilizing Core resources. The Neuroimaging Core is also highly committed to the mentoring of junior faculty, and pre- and post-doctoral trainees in the validation and translation of advanced brain imaging techniques to aging and AD research.