ALZHEIMER'S DISEASE RESEARCH CENTER IMAGING CORE SUPPLEMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 开发具有早期诊断能力的非侵入性工具的必要性源于最近有效形式的阿尔茨海默病（AD）药物治疗的可用性。 匹兹堡大学阿尔茨海默病研究中心（ADRC）的神经成像核心支持研究患者的结构和功能磁共振成像（MRI），并为开发最先进的结构和功能MRI以及正电子发射断层扫描（PET）成像提供基础设施。 我们的ADRC竞争更新和我们的外部咨询委员会的审查员的综合输入支持我们的目标，广泛标准化的MRI数据收集的ADRC主题，以及控制，以开发一个“体内脑银行”。 这一概念将成为匹兹堡大学老龄化和痴呆症研究人员的一个非常宝贵的资源。 因此，我们正在申请额外的资金支持，用于对特征明确的健康老年人和特定患者亚组（例如轻度认知障碍）进行结构和功能成像，以专门满足ADRC研究人员的需求。 这些数据还将作为实施和传播一套方法学工具的基础，这些工具旨在改善对衰老大脑成像研究的解释。 该竞争补充申请支持ADRC神经影像核心的总体目标，即继续开发和分发用于获取和解释结构和功能图像数据的技术，以支持AD研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An imperative for developing non-invasive tools with early diagnostic capability has resulted from the recent availability of effective forms of pharmacotherapy for Alzheimer¿s disease (AD). The Neuroimaging Core of the University of Pittsburgh Alzheimer's Disease Research Center (ADRC) supports structural and functional magnetic resonance imaging (MRI) in research patients and provides the infrastructure for developing state-of-the-art structural and functional MRI and positron emission tomographic (PET) imaging in aging and dementia. The combined input from the reviewers of our ADRC Competing Renewal and our External Advisory Committee has supported our goal of widely standardizing the MRI data collected on ADRC subjects, as well as controls, in order to develop an "in vivo brain bank". This concept would serve as a highly valuable resource for the large community of investigators of aging and dementia at the University of Pittsburgh. Therefore, we are requesting additional funding support of structural and functional imaging of well-characterized healthy elders and specific patient subgroups of interest (e.g. mild cognitive impairment) to specifically address the needs of ADRC investigators. These data will also serve as the basis for implementing and disseminating a set of methodologic tools designed to improve the interpretation of imaging studies of the aging brain. This application for a competititve supplement is in support of the overarching aim of the ADRC Neuroimaging core to continue to develop and distribute technology for acquiring and interpreting structural and functional image data in support of AD research.