Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 7464278
• 负责人: DAVID P HARRINGTON
• 金额: $ 18.42万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7464278
• 关键词: Bioinformatics; Biometry; Biostatistics Core; Clinical; Computers; Consult; Consultations; Dana-Farber Cancer Institute; Data; Data Collection; Data Quality; Databases; Development; Education; Epidemiologic Studies; Experimental Designs; Individual; Informatics; Laboratory Animals; Manuscripts; Methods; Monitor; Online Systems; Patients; Physicians; Preparation; Protocols documentation; Purpose; Reporting; Reproduction spores; Research Infrastructure; Research Personnel; Resources; Sample Size; Skin Cancer; Staging; Work; data management; database design; design; melanoma; outcome forecast; predictive modeling; prognostic; programs; research study

The purpose of the Biostatistics Core is to provide design and analytic support to SPORE Projects, Developmental Projects, and other Cores. This core has three specific aims. 1. To provide biostatistical expertise for the planning, conduct, analysis, and reporting of laboratory, animal, clinical, and epidemiological studies for SPORE projects and developmental projects. The Biostatistics Core will work with SPORE researchers on protocol and experimental design, and will provide estimates of sample size and statistical power. The Core will advise researchers about optimal methods for monitoring ongoing studies. The Core will provide statistical analyses of completed experiments, and participate in manuscript preparation. 2. To provide or recommend supporting computational infrastructure, including computer databases, statistical computer packages, publicly available statistical programs and data sharing between computers or databases. Because an effective informatics infrastructure is critical to the functioning of the SPORE, the Biostatistics Core will work to assure that the storage and accessibility of data used and generated by the SPORE is efficient and effective. The Biostatistics Core will support efficient management of data resources by consulting on database design, helping to design efficient data collection methods and conducting audits of data quality. 3: To provide consulting and statistical education to SPORE researchers. In addition to formal collaborative efforts, the Biostatistics Core will be available for ongoing, informal consultation with researchers over the duration of the SPORE. In addition the Biostatistics Core will work with investigators within the DF/HCC Skin Cancer SPORE, other Skin Cancer SPOREs and Cooperative Groups to attempt to build a prognostic and predictive model for melanoma patients with a web-based statistical product that will help physicians define the prognosis and select the optimal therapy for individual patients with various stages of melanoma.

生物统计学核心的目的是为SPORE项目提供设计和分析支持， 开发项目和其他核心。该核心有三个具体目标。 1.为实验室，动物， 为SPORE项目和发展项目进行临床和流行病学研究。生物统计学核心 将与SPORE研究人员合作进行方案和实验设计，并将提供 样本量和统计功效。核心将建议研究人员关于监测的最佳方法 正在进行的研究。核心将提供已完成实验的统计分析，并参与 手稿准备。 2.提供或推荐支持计算基础设施，包括计算机数据库， 统计计算机软件包、公开可用的统计程序和计算机之间的数据共享， 数据库。由于有效的信息学基础设施对SPORE的功能至关重要， 生物统计学核心将努力确保使用和生成的数据的存储和访问 SPORE高效且有效。生物统计学核心将支持数据资源的有效管理 通过咨询数据库设计，帮助设计有效的数据收集方法和进行审计 数据质量。 3：为SPORE研究人员提供咨询和统计教育。除了正式的合作 通过努力，生物统计学核心将可用于与研究人员进行持续的非正式磋商， 孢子的持续时间。 此外，生物统计学核心将与DF/HCC皮肤癌孢子内的研究者合作， 皮肤癌SPORE和合作小组，试图建立一个预后和预测模型， 黑色素瘤患者与基于网络的统计产品，将帮助医生确定预后， 为不同阶段的黑色素瘤患者选择最佳治疗方法。