Whole Eye Biometry System

全眼生物测量系统

• 批准号: 9274928
• 负责人: R DANIEL FERGUSON
• 金额: $ 47.03万
• 依托单位: PHYSICAL SCIENCES, INC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274928
• 关键词: Address; Anatomic Surface; Anatomy; Anterior; Biometry; Boston; Clinical; Clinical Research; Cornea; Crystalline Lens; Data; Devices; Diagnosis; Diagnostic; Disease; Evaluation; Exhibits; Eye; Geometry; Goals; Government; Health; Human; Image; Incidence; Length; Light; Location; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Marketing; Measurement; Measures; Methods; Modeling; Monitor; Ophthalmic examination and evaluation; Optics; Pathology; Patients; Pediatric Hospitals; Penetration; Persons; Phase; Positioning Attribute; Progress Reports; Protocols documentation; Pupil; Research; Resolution; Retina; Retinal; Scanning; Sclera; Shapes; Speed; Structure; Surface; System; Techniques; Technology; Testing; Thick; Tissues; Ultrasonographic Biomicroscopy; Validation; arm; base; clinical application; design; flexibility; human subject; image processing; imaging modality; imaging system; improved; innovation; instrument; instrumentation; lens; novel; ocular surface; optical imaging; physical science; programs; sample fixation; signal processing; spatial relationship

 DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI) proposes to demonstrate a new dual-conjugate, dual-band approach to whole eye optical biometry. We will adapt a high-speed SDOCT-based scanning/imaging system design, recently developed for corneal/scleral topography, for application to the whole eye. That system was based upon an ellipsoidal optical scanning/imaging design that produces near-normal incidence scans over large patches of the eye's surface for efficient profiling and corneal/scleral surface stitching. Te proposed innovation described herein extends this method, permitting simultaneous imaging of pairs of ocular surfaces with respect to the scan pivot point (the system pupil), by integration of dual-conjugate optics. Coordinated dual- reference arms enable ranging to these two focal surfaces at precisely known locations with respect to the scan pivot, and to each other, on a single SDOCT spectrometer without imposing extreme requirements on the axial imaging range. Direct imaging of the eye through the reflective scan optics allows the system pupil/pivot location to be precisely positioned by the operator, while the eye's position and orientation are monitored by a camera and controlled by a fixation display. Refractive models of the eye will be used to complete physical interior surface shape estimation. Together with our collaborators at Children's Hospital Boston, we will test and validate the whole eye biometry device for quantitative characterization of certain classes of eye conditions.

 描述(由申请人提供)：物理科学公司(PSI)建议展示一种新的双共轭、双波段方法来进行全眼光学生物测量。我们将采用一种基于SDOCT的高速扫描/成像系统设计，该系统最近开发用于角膜/巩膜地形图，用于全眼。该系统基于椭球体光学扫描/成像设计，在眼睛表面的大片区域产生近乎正常的入射扫描，以实现有效的轮廓分析和角膜/巩膜表面缝合。在此描述的TE提出的创新扩展了该方法，允许相对于扫描枢轴点(系统光瞳)同时成像成对的眼睛表面，通过集成 双共轭光学系统。协调的双参照臂能够在单个SDOCT光谱仪上精确测量这两个焦面相对于扫描枢轴的位置，并相互测距，而不会对轴向成像范围提出极端要求。通过反射式扫描光学对眼睛的直接成像允许操作员精确定位系统的瞳孔/枢轴位置，而眼睛的位置和方向由摄像机监控并由固定显示器控制。眼睛的屈光模型将用于完成物理内表面形状的估计。我们将与波士顿儿童医院的合作伙伴一起，测试和验证全眼生物测量设备，以定量描述某些类别的眼睛状况。