SPORE in Head and Neck Cancer

描述(由申请者提供)：埃默里大学温斯顿癌症研究所(Emory WCI)建议开展一项针对头颈癌(HNC)的专业卓越研究计划(Spoor)。Emory WCI HNC孢子的总体目标是改善头颈部癌症的预防和治疗，重点是新发现，快速转化为因这种疾病而遭受痛苦、残疾和发病率的患者。孢子计划将由四(4)个主要的翻译研究项目、两个研究核心、一个行政核心、一个发展研究计划和一个职业发展计划组成。WCI HNC孢子将使用跨学科的方法，通过与基础、翻译和临床科学的合作研究人员开展项目来实现其目标。所有项目都将测试有关生物学、预防、分子和纳米技术驱动的新治疗方法的假设。这四(4)个主要项目是：(1)绿茶多酚E和EGFR-TKIs在HNC中的化学预防；(2)针对死亡受体介导的HNC的凋亡；(3)用于治疗头颈部癌症的新型姜黄素类似物的开发；(4)用于HNC靶向治疗的可生物降解纳米粒配方紫杉醇。我们孢子计划中的每个项目都以明确定义的翻译目标为中心，包括与核心密切互动的试点临床试验(项目1，化学预防第一阶段研究；项目2，生物标记物研究；项目3，EF24 0阶段试验；项目4，1b阶段临床研究)。这两个研究核心(标本资源和病理学核心、生物统计学和数据管理核心)将协助主要研究项目、发展研究项目和职业发展研究人员进行头颈部癌症的转化研究。行政核心将为孢子计划提供科学和财务监督。我们还得到了来自埃默里·温希普癌症研究所、埃默里大学医学院、埃默里大学伍德拉夫健康科学中心、佐治亚州癌症联盟(GCC)和佐治亚州研究联盟(GRA)的坚定承诺的支持，包括空间、招聘、共享资源和匹配资金。埃默里WCI HNC孢子研究人员将作为一个团队密切合作，以实现该计划的目标，并将与其他机构和其他研究计划的HNC孢子研究人员互动，以改善头颈癌患者的结果。

DESCRIPTION (provided by applicant): The Emory University Winship Cancer Institute (Emory WCI) proposes to conduct a Specialized Program of Research Excellence (SPORE) for Head and Neck Cancer (HNC). The overall goal of the Emory WCI HNC SPORE is to improve prevention and treatment of head and neck cancer with emphasis on new discoveries, rapid translation to patients who are suffering, disability and morbidity caused by this disease. The SPORE program will consist of four (4) major translational research projects, two research cores, an administrative core, a developmental research program, and a career development program. The WCI HNC SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with coinvestigators in basic, translational, and clinical science. All projects will test hypotheses about biology, prevention, molecularly and nanotechnology driven novel therapeutic approaches. The four (4) main projects are: (1) Chemoprevention with Green Tea Polyphenon E and EGFR-TKIs in HNC; (2) Targeting Death Receptors-Mediated Apoptosis for HNC; (3) Development of Novel Curcumin Analogs for the Treatment of Head and Neck Cancer, (4) Biodegradable Nanoparticle Formulated Taxol for Targeted Therapy of HNC. Each project in our SPORE program is centered on clearly defined translational objectives including pilot clinical trials (project 1, Phase I Study of Chemoprevention; project 2, biomarker studies; project 3, phase 0 trial of EF24; project 4, phase 1b clinical study) that have close interaction with the cores. The two research cores (Specimen Resources and Pathology Core, Biostatistics and Data Management Core) will assist the main research projects, developmental research projects, and career developmental investigators in performing head and neck cancer translational research. The Administrative Core will provide scientific and financial oversight for the SPORE program. We also have a strong commitment of support including space, recruitment, shared resources and matching funds from the Emory Winship Cancer Institute, Emory University School of Medicine, Woodruff Health Science Center at Emory University, Georgia Cancer Coalition (GCC), and the Georgia Research Alliance (GRA). The Emory WCI HNC SPORE investigators will work closely together as a team to achieve the goals of the program and will also interact with investigators from HNC SPORES at other institutions and other research programs to improve outcomes for head and neck cancer patients.