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Molecular characterisation of TRAIL-regulated signal transduction pathways and their role in the development, persistence, and exacerbation of allergic airways disease

Molecular characterisation of TRAIL-regulated signal transduction pathways and their role in the development, persistence, and exacerbation of allergic airways disease
TRAIL 调节信号转导途径的分子特征及其在过敏性气道疾病的发生、持续和恶化中的作用
批准号:
nhmrc : 1011153
负责人:
Dr Nicole Verrills
金额:
$42.48万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2014-12-31

项目摘要

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相关文献

中文摘要
翻译
促进哮喘发展、持续和恶化的分子定义不明确。我们已经发现了一种新的信号通路,在哮喘期间在气道壁中被激活。阻断激活这一通路的分子可以改善小鼠的哮喘。我们现在想确定这一途径的所有重要组成部分,并对它们进行治疗性调节,以预防哮喘的发展、持续和恶化。
英文摘要
Molecules that promote the development, persistence, and exacerbation of asthma are only poorly defined. We have discovered a novel signalling pathway that is activated in the airway wall during asthma. Blocking a molecule that activates this pathway ameliorated asthma in mice. We now want to identify all the important components of this pathway and therapeutically modulate them to prevent the development, persistence, and exacerbation of asthma.
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会议论文
Switching tristetraprolin on to turn off inflammation in COPD
  • 批准号:
    nhmrc : GNT1141365
  • 项目类别:
    Project Grants
  • 资助金额:
    $52.54万
  • 财政年份:
    2018
  • 负责人:
    Dr Nicole Verrills
  • 依托单位:
The role of protein phosphatases in regulating the cytoskeletal dynamics of cancer cells
  • 批准号:
    nhmrc : 401304
  • 项目类别:
    Early Career Fellowships
  • 资助金额:
    $19.5万
  • 财政年份:
    2006
  • 负责人:
    Dr Nicole Verrills
  • 依托单位:
海外基金